ID F8JLQ6_STREN Unreviewed; 972 AA.
AC F8JLQ6; G8XFQ3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:AEW99514.1};
GN OrderedLocusNames=SCATT_p13210 {ECO:0000313|EMBL:AEW99514.1};
OS Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925
OS / NBRC 14057 / NRRL 8057) (Streptomyces cattleya).
OG Plasmid pSCATT {ECO:0000313|EMBL:AEW99514.1,
OG ECO:0000313|Proteomes:UP000007842}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptantibioticus.
OX NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW99514.1, ECO:0000313|Proteomes:UP000007842};
RN [1] {ECO:0000313|Proteomes:UP000007842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC {ECO:0000313|Proteomes:UP000007842};
RC PLASMID=Plasmid pSCATT {ECO:0000313|Proteomes:UP000007842};
RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003229; AEW99514.1; -; Genomic_DNA.
DR AlphaFoldDB; F8JLQ6; -.
DR KEGG; scy:SCATT_p13210; -.
DR PATRIC; fig|1003195.11.peg.403; -.
DR HOGENOM; CLU_000022_16_6_11; -.
DR Proteomes; UP000007842; Plasmid pSCATT.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Plasmid {ECO:0000313|EMBL:AEW99514.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007842}.
FT DOMAIN 11..465
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 937..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..972
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 102157 MW; 85ADF7A120DA598D CRC64;
MVDSHAYQPS GHPVAIVGLA AMFPQAHDVR EFWDNVVTGR DCVTDVPETS WSVADHYDPD
MRAPDKTYAR RGGFLPPVVF DPVEFAMPPA TLDSIGLVQL LSLRVAREVL RDAGCPGAAW
YDPGRTGVVL GVCGQNSTMV PLASRLRAPA VRRAALSCGL SPRDADEIAR RFLAESPEWT
EDSFPGILAN VVAGRIANRF GLGAANCVVD AACASSLAAL RMAVSELVEH RADLMITGGC
DADNSVTTFL CFSKTPALSP SGAVRPFDRE ADGTLLGEGI GMLALKRLAD AERDGDRVYA
VLRGLGGSSD GRTGSIYAPS ADGQVTAMRR AYADAGVPAA SVELIEAHGT GTRVGDTVEL
GALRTVLGPA PDRPRIAVGS VKSQIGHTKA AAGAAGLIKA ALALHHRLLP PTINVTEPND
ALRDSALYVN TRARPWIRDP ARPVRRAGVS SFGFGGVNFH AVLEEHPPTP PRTLHRTPRA
LVWHAPDPAA LLALVRDGAD PADGGPVPPH HARLGVLVHD AADREALLAA ATARLSDTPD
ADGWTLAGRA HYRRSGLPPD ARAAVLFAGQ GSQYVGMGAD ALLAVPPVRR AFDDANALWE
GEEETLAQVV HPEPGRRDPA ADTARLRRTA YAQPAIGALA MGHYAYLAEL GFAPAAALGH
SCGEVTALWS AGSLSDADCL LLTRRRGQAM RPAPGGTDRD AGAMAAVRLS AEEWRQRAQN
FPQLALCNIN APDEIVVGGP TPAVEELAAA CLRDGGPAVR RLPVAAAFHT PLMAHAVPVF
AEAVSRTEVR PPAHPVLACT PGARYGTDPE ADRRVLAEQI TRPVDFAGRV RELYDDGCRV
FVECGPKGIL SRLVRRTLGD ATVETVPADT GPGTDSAAAL KNAALRLAVL GFGIRHINRY
DAPDPPPPAP PSPVARRLAG PVFAMRARRA AYEAGLAVPY RCTPTGPPPD RSAAPGPADA
PQPPTSPPPR PL
//
