ID F8L7C1_SIMNZ Unreviewed; 731 AA.
AC F8L7C1;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=yrrC {ECO:0000313|EMBL:CCB88646.1};
GN Synonyms=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN OrderedLocusNames=SNE_A07690 {ECO:0000313|EMBL:CCB88646.1};
OS Simkania negevensis (strain ATCC VR-1471 / Z).
OC Bacteria; Chlamydiota; Chlamydiia; Parachlamydiales; Simkaniaceae;
OC Simkania.
OX NCBI_TaxID=331113 {ECO:0000313|EMBL:CCB88646.1, ECO:0000313|Proteomes:UP000000496};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Z;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S.A., Horn M.;
RT "Unity in variety -- the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 0:0-0(2011).
RN [2] {ECO:0000313|EMBL:CCB88646.1, ECO:0000313|Proteomes:UP000000496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1471 / Z {ECO:0000313|Proteomes:UP000000496};
RX PubMed=21690563; DOI=10.1093/molbev/msr161;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S., Horn M.;
RT "Unity in variety--the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 28:3253-3270(2011).
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
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DR EMBL; FR872582; CCB88646.1; -; Genomic_DNA.
DR RefSeq; WP_013943113.1; NC_015713.1.
DR AlphaFoldDB; F8L7C1; -.
DR STRING; 331113.SNE_A07690; -.
DR KEGG; sng:SNE_A07690; -.
DR eggNOG; COG0507; Bacteria.
DR HOGENOM; CLU_007524_0_3_0; -.
DR OrthoDB; 9803432at2; -.
DR Proteomes; UP000000496; Chromosome gsn.131.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000000496}.
FT DOMAIN 140..230
FT /note="RecD helicase-like helix-hairpin-helix"
FT /evidence="ECO:0000259|Pfam:PF14490"
FT DOMAIN 561..621
FT /note="RecD-like DNA helicase SH3"
FT /evidence="ECO:0000259|Pfam:PF18335"
FT DOMAIN 638..685
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13538"
FT BINDING 345..349
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 731 AA; 83085 MW; FC84020799739B58 CRC64;
MDQLSGYIEN IVFSSEENGF TVARLKQPRE KDLTTITGTM PGINPGETIH CRGKWKHHPK
HGRQFEVESY ELTAPVDVLG IQKYLESGMV KGIGPIYAKR IVEFFGVETL KIIDKFPYRL
LEVPGIGEKR VQQIETCWDE QKSIRRVMIF LQSHKVSPSF ARKIFKTYGE DSIEKVTENP
YALARDIFGI GFKTADQLAQ NMGIEKDASI RIQAGVEYVL WELSNDGHVC YPIELFLKDA
EAILEVAPEK IRQEIDTLDE AKRIVKGEAN KEPSIWIRPL FMAELGIARE LKRIHDGECS
IRSVLIDKAV EWAEEKLRMR FAKEQKIAIE KSLSEKLHVV TGGPGTGKST ITRAILSITS
KLTDKITLAA PTGRAAKRLS EITYKKAFTI HSLLEVNFQE GGFKRNKDNP LKCRLLIIDE
ASMIDTQLMY HLLKAIPDET RVIFIGDIDQ LPSVGPGTVL KDLIESERIS VTRLKHIFRQ
GRGSRIVQSA HRINAGYFPE LSYDAESDFN FLEIENPEEI LTRTVSLIKK EIPQKFGFDP
INEIQVLSPM KRGLIGIDNF NHILQKELNP QSMQLLRMGR IFQPQDKVMQ IRNNYDKHVY
NGDVGRIQEM DLEEQKLTVD FDGKTVSYDF SELDELMLAY AVSIHKYQGS ECPCVIIPVH
VSHFKLLFRN LLYTGLTRGK KLVLLLGTKK ALAIAINTDN AQKRYTGLRE LLSEAIQGQE
SEKSETILIN P
//
