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Database: UniProt
Entry: F8L903_SIMNZ
LinkDB: F8L903_SIMNZ
Original site: F8L903_SIMNZ 
ID   F8L903_SIMNZ            Unreviewed;       430 AA.
AC   F8L903;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   25-OCT-2017, entry version 48.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA1-B {ECO:0000313|EMBL:CCB89311.1};
GN   OrderedLocusNames=SNE_A14340 {ECO:0000313|EMBL:CCB89311.1};
OS   Simkania negevensis (strain ATCC VR-1471 / Z).
OC   Bacteria; Chlamydiae; Parachlamydiales; Simkaniaceae; Simkania.
OX   NCBI_TaxID=331113 {ECO:0000313|EMBL:CCB89311.1, ECO:0000313|Proteomes:UP000000496};
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Z;
RA   Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E.,
RA   Brunham R.C., Read T.D., Bavoil P.M., Sachse K., Kahane S.,
RA   Friedman M.G., Rattei T., Myers G.S.A., Horn M.;
RT   "Unity in variety -- the pan-genome of the Chlamydiae.";
RL   Mol. Biol. Evol. 0:0-0(2011).
RN   [2] {ECO:0000313|EMBL:CCB89311.1, ECO:0000313|Proteomes:UP000000496}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1471 / Z {ECO:0000313|Proteomes:UP000000496};
RX   PubMed=21690563; DOI=10.1093/molbev/msr161;
RA   Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E.,
RA   Brunham R.C., Read T.D., Bavoil P.M., Sachse K., Kahane S.,
RA   Friedman M.G., Rattei T., Myers G.S., Horn M.;
RT   "Unity in variety--the pan-genome of the chlamydiae.";
RL   Mol. Biol. Evol. 28:3253-3270(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; FR872582; CCB89311.1; -; Genomic_DNA.
DR   RefSeq; WP_013943778.1; NC_015713.1.
DR   STRING; 331113.SNE_A14340; -.
DR   EnsemblBacteria; CCB89311; CCB89311; SNE_A14340.
DR   KEGG; sng:SNE_A14340; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000496; Chromosome gsn.131.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000496};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000496}.
FT   DOMAIN      128    256       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      337    405       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   430 AA;  49895 MW;  5D7B2DA95D0761AE CRC64;
     MRTWHDFLKM LEKDLGKETV DKWLRPLKIL KFDAANLYLD ATDSFQILWY KEHVTKELMD
     PNGRKIKLHF YLNGQPLKSR VKKTTTEESS PKQYFSPDHL ASHATFENFI KEESPFLACD
     LLTHIDSTYN PIFLYGPSGC GKTHLLMATA HKLKKDGKNV FYVRAETFTE HVIRAFRTSS
     LQEFRPTYRN LDCLILDDIQ MLKGKNTTQE ELFHTFNRLH TQGMQIVLSS SSSPRELDGI
     EERLKSRFEW GITLPLSVAT SSECKQILAK RSESLSLPLT ELMQTHLLRT FQTLPSLIRA
     LEALALRLHQ SQLKLDISMI DHLLQDLIRE EKGQQLTPDI ILQHIAETFQ VNAEDIMGKS
     QNKEHVLPRK MAMYFCRTIL RMPYLKIGEF FSRDHSTVMS SVKQIEKGKA SKDKNIAPAL
     FQIQQKFLNY
//
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