ID F8MC28_NEUT8 Unreviewed; 246 AA.
AC F8MC28;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Nucleotide exchange factor Fes1 domain-containing protein {ECO:0000259|Pfam:PF08609};
GN ORFNames=NEUTE1DRAFT_75392 {ECO:0000313|EMBL:EGO60382.1};
OS Neurospora tetrasperma (strain FGSC 2508 / ATCC MYA-4615 / P0657).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510951 {ECO:0000313|EMBL:EGO60382.1};
RN [1] {ECO:0000313|EMBL:EGO60382.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FGSC 2508 {ECO:0000313|EMBL:EGO60382.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ellison C.E., Stajich J.E., Jacobson D.J., Lindquist E., Lapidus A.,
RA Foster B., Aerts A., Riley R., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC chaperones which accelerates the release of ADP. Required for fully
CC efficient Hsp70-mediated folding of proteins.
CC {ECO:0000256|ARBA:ARBA00024912}.
CC -!- SIMILARITY: Belongs to the FES1 family.
CC {ECO:0000256|ARBA:ARBA00011045}.
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DR EMBL; GL891302; EGO60382.1; -; Genomic_DNA.
DR RefSeq; XP_009847675.1; XM_009849373.1.
DR AlphaFoldDB; F8MC28; -.
DR GeneID; 20829802; -.
DR KEGG; nte:NEUTE1DRAFT75392; -.
DR VEuPathDB; FungiDB:NEUTE1DRAFT_75392; -.
DR HOGENOM; CLU_084507_0_0_1; -.
DR OrthoDB; 5473057at2759; -.
DR Proteomes; UP000008065; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR PANTHER; PTHR19316:SF18; HSP70-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR19316; PROTEIN FOLDING REGULATOR; 1.
DR Pfam; PF08609; Fes1; 1.
DR SMART; SM00185; ARM; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
FT DOMAIN 5..119
FT /note="Nucleotide exchange factor Fes1"
FT /evidence="ECO:0000259|Pfam:PF08609"
FT REPEAT 165..193
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 22..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 26574 MW; 62989334AD40DAB3 CRC64;
MDKNLNQLLK WSLEAQTAAN AGQSYNSNGA PTSNNNSGPA TGTGAVATSP APQVTGSGPR
PVDPEVLASL FGGPSEAELM KAAMEVITDP SPETTRENKL IAFDNFEQLI ENLDNANLLE
ELSLWSPLIS LLDHEDEDMR YHAAWCLGTA VQNNQKTQER LLAMGGVPKL VDLAMKEGES
EKVRRKATYA LSSAVRNYQP AMDVAADEMH KRGHEVLVNN GTKVDAADMD KVDEVIDVLR
NKAKSA
//
