ID F8MXE2_NEUT8 Unreviewed; 1030 AA.
AC F8MXE2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=FAD-binding FR-type domain-containing protein {ECO:0000259|PROSITE:PS51384};
GN ORFNames=NEUTE1DRAFT_131946 {ECO:0000313|EMBL:EGO54413.1};
OS Neurospora tetrasperma (strain FGSC 2508 / ATCC MYA-4615 / P0657).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510951 {ECO:0000313|EMBL:EGO54413.1};
RN [1] {ECO:0000313|EMBL:EGO54413.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FGSC 2508 {ECO:0000313|EMBL:EGO54413.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ellison C.E., Stajich J.E., Jacobson D.J., Lindquist E., Lapidus A.,
RA Foster B., Aerts A., Riley R., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; GL891307; EGO54413.1; -; Genomic_DNA.
DR RefSeq; XP_009854372.1; XM_009856070.1.
DR AlphaFoldDB; F8MXE2; -.
DR GeneID; 20825594; -.
DR KEGG; nte:NEUTE1DRAFT131946; -.
DR VEuPathDB; FungiDB:NEUTE1DRAFT_131946; -.
DR HOGENOM; CLU_003662_1_0_1; -.
DR OrthoDB; 5488444at2759; -.
DR Proteomes; UP000008065; Unassembled WGS sequence.
DR GO; GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IEA:UniProtKB-EC.
DR GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR CDD; cd06207; CyPoR_like; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR PANTHER; PTHR19384:SF109; SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR Pfam; PF01558; POR; 1.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 643..874
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 1030 AA; 112807 MW; F000D9293222D6A9 CRC64;
MPSLSSISGP TYVTSQLLVQ QTAYKLSDKI FSYSPETFDL DVAVKEWAEA NEKNVHGETT
TVVPLQTRAG AGAFALGYIF SKDFDLAKRH VPQTLLAPSL SLRHLRSSLD QLALLYGVSS
PFVAHVAAAD YSAEKGLGAD YATALQIAED LGLALVSSSS AYEVQHMSLL ATLLASVLPT
LHIYDGIRTA RESLRVVDAL GEAHIADVYA KISKEAAALN KRLDTAGKVV ELLKAFNNEL
GTSYAPFEYH GHEAPETVLV VFGSAEAQLA KQVASALAAE GKKVGTIVVR VYRPFVEEAF
LEVLPASVRQ IAVLGQVADA AAVEDANVQS ALYSDVLTAV SFTDKLSQAP EVVDVRYAVT
DAHTPSSIAS IFNKLTSKGE AEPVAFSLTA VEEAQQYVFW DVDNSSAAAS ASAVGRLLET
EQSNNVYVHQ TYDNLVQGGV VRTDIRVSQK SIEAPYPVES ADVVFVGEEK LLKEIAIVKG
VKAGGKLIVR LPNFKEDELE KRIPAAAQKE IQEKGIELYV LDSSSSPALE KEAGLLVGVA
FLRVARADIT KLDSLSADQT ALTEAVNALD QSVRKVEVPA KWAEVENTVA PLVDSVKPNS
FVAFQKEEEE ETSSLENWQS AAKGFAFKEA YGTQNQLRPD LTVKTYTIKV KENRRLTPTD
YDRNIFHIEF DLGDSGLTYN IGEALGIHAD NDPEQVLQFI QAYGLNADDL VQVPSREDPA
VLETRTVYQS LVQNVDILGK PPKRFFEALA QFATDEEEKK KLERLGSKEG ADEFKRLTEE
DTVTYVDVLD MFKSAHPDFN DLVRIVDPTK RREYSIASAQ AVTPNSVTLM IVVVNWVDTK
GRTRYGHATR YLSGLAPGST ITASVKPSVM KLPVKDTAPL IMAGLGTGLA PFRAFVQYRA
MQKAQGKEIG SILLYLGSRH QREEYLYGEE WEAYLDAGVI TLLGAAFSRD QPEKIYIQDR
MRQTVTDIVK AYIKEEGSFY LCGPTWPVPD VTAVLEEAIA AEAQESSRKV DPRKEIERLK
EDGRYVLEVY
//
