ID   F8NY57_SERL9            Unreviewed;       856 AA.
AC   F8NY57;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SERLADRAFT_449565 {ECO:0000313|EMBL:EGO24819.1};
OS   Serpula lacrymans var. lacrymans (strain S7.9) (Dry rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX   NCBI_TaxID=578457;
RN   [1] {ECO:0000313|EMBL:EGO24819.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S7.9 {ECO:0000313|EMBL:EGO24819.1};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA   Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA   Coutinho P.M., Cullen D., Cullen D., Gathman A., Goodell B., Henrissat B.,
RA   Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A., Lavin J.L.,
RA   Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E., Murat C.,
RA   Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A., Salamov A.,
RA   Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A., Xie X.,
RA   Kues U., Hibbett D.S., Hoffmeister D., Hogberg N., Martin F.,
RA   Grigoriev I.V., Watkinson S.C.;
RT   "Evolution of plant cell wall degrading machinery underlies the functional
RT   diversity of forest fungi.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL945434; EGO24819.1; -; Genomic_DNA.
DR   RefSeq; XP_007318838.1; XM_007318776.1.
DR   AlphaFoldDB; F8NY57; -.
DR   GeneID; 18816564; -.
DR   KEGG; sla:SERLADRAFT_449565; -.
DR   HOGENOM; CLU_005275_0_0_1; -.
DR   OrthoDB; 5100844at2759; -.
DR   Proteomes; UP000008064; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041675; PH_5.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF15405; PH_5; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          96..287
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          322..450
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          487..798
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   856 AA;  95925 MW;  E2CA306F556BA322 CRC64;
     MATMAFPEPE IHRAASQRKS LHPDHHVYPG HRSSKSDVGH SPPSIPPYSP TSPSSTLQSE
     EGLRHFQAGE LAESDEEWYR LVPEEAREAL GKHEVERQSV LFEVFKSERD YVSDMELVRE
     VFTEPLQSAS PPVIPQERLQ GFVREVFWNL DQILSHHQRM LGSLFARQRD QHPLVQSVTD
     IILETSFQFR NEYESYIKHY PLAEEGHRAE LKSNQKYQEF IQQCSHDPRI RKRDLITFLS
     RPVTRLPRLS LVLEHIHKLT DTEHPDFEDL PVIMSILSDF IKSTQPGIAA AENKVKFWNI
     CESLVYMNGE IIDIDRYDES RSLVYSGPLA RRSKSEMDWH GWNDLLVVLF DNYLLLLQEK
     KVGSMTKRYV VSRPLPLEFL RLGSFDAPLE NRKERSEEGG LLDSFRAQSK PVYPFTVFHA
     ASKGSRRYTL YAVSEAVRKK WRDAMVDAMG VHNARRDGNK WFAPQPLDDG FFRSIGGRTF
     LTGTKVTGAV TSAVSFVASG GRSFLAVGCA TGIYVGPRGE GGYRKVLSLT SPSALIALQE
     YNKLVVHHDT YLVAYSLDLL VRVALKQTPP GSLDASLEKI AGHDGNVLFC KAGRLGTRTT
     IIYAVKTFLQ VTVHIEEAIN PGTLSAAPRR ANDNGSLSFR PFGGPLYVPK DAYNVTPLTK
     MVAISTEKGI IIVNSTSPTK SGIVLVPDFS DAHNSKAMTD LKSRCEAAKP LGLVRSGASE
     LLVIYDTMGC YITKHGVPCR SSGFVRWETS VTTFAQRGDH VLLFSSDFIE VRNISKGRLV
     QVIEGSDIRL LQHNSLSEDR TDDNLLVGMK GEKNDKEGIS DKILELVETT EFNSLQAPST
     ANAVANVGGI WDEWDM
//