ID F8Q0S5_SERL3 Unreviewed; 750 AA.
AC F8Q0S5;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Trehalase {ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN ORFNames=SERLA73DRAFT_182692 {ECO:0000313|EMBL:EGN97904.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|ARBA:ARBA00001576,
CC ECO:0000256|RuleBase:RU361180};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
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DR EMBL; GL945481; EGN97904.1; -; Genomic_DNA.
DR AlphaFoldDB; F8Q0S5; -.
DR STRING; 936435.F8Q0S5; -.
DR eggNOG; KOG0602; Eukaryota.
DR HOGENOM; CLU_006451_4_0_1; -.
DR InParanoid; F8Q0S5; -.
DR OMA; NRYWDAS; -.
DR OrthoDB; 1329212at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR001661; Glyco_hydro_37.
DR InterPro; IPR018232; Glyco_hydro_37_CS.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR PANTHER; PTHR23403:SF1; TREHALASE; 1.
DR Pfam; PF01204; Trehalase; 2.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR PROSITE; PS00927; TREHALASE_1; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008063};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..750
FT /note="Trehalase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003382493"
SQ SEQUENCE 750 AA; 81220 MW; F2E4C65BAA17517F CRC64;
MLTKRLHLAA LAGLAHWHGV LAAPSGTATA PFTVQTGVPT LTFSTSVPSP SASLGATLPS
QVALPPSQWW CIGQIFCAGS LLQTVNVAQL YPDPKTFVDK PTKKSSQQVL SDFGAFNVST
VTEGDLVNFV DNDFSGEGLE LEGIALQGFN ANPPFLNNVS DPLLRSFAQI VNSYWTQLAR
STNYSSTCDD YPGGQCEGSF IPLNHSFVIP GGRFREQYYW DSYWIIQGLI QSQLYESING
TLQNFMDEIE TFGFIPNGGR IYYLNRSQPP LFIHMLYDYV TATNDSSILE RALPLAEVEL
TWWQNNRTSE VTSPFTGQTY AMARYAVTNT APRPESYLTD YLTANDPTLT TPLTEEQRAD
LYGELASGAE TGWDYTARFE SIPALGNPGL RSLNVSNNIP VCLNSILYKA HILLADLYGS
SNASAAATHL QVAAGIRAGI LDLFWNSTKL AFYDFNLTSN ARNDIFTAAT FYPLWNGIIP
DEVLSSQENA FGFFASLNMV FNRYNGTFPT TFIDYTGLQW DAPNTWPPHQ YIALQALRAL
PSNLTSNPLP TPPSNESAYS LVPVGQLALT EAQLPGQPLR GPQANQNVTQ TGPGADLNAL
NGTVVNGGNA TAGEGWNHVL QRELANRFFT SALCSWHATG GSIPGYLPQL SPAELNVTNS
IGNTGNMFEK FSNLNVDSSG FGGEYTVQAG FGWTNGAVLW VAATYGDLLV APECPPLLYT
STNAATGLRS SSAAVLLAVV VSLLFHSLLS
//
