ID F8Q427_SERL3 Unreviewed; 1474 AA.
AC F8Q427;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=VPS10 domain-containing protein {ECO:0000259|SMART:SM00602};
GN ORFNames=SERLA73DRAFT_170248 {ECO:0000313|EMBL:EGN96883.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
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DR EMBL; GL945483; EGN96883.1; -; Genomic_DNA.
DR STRING; 936435.F8Q427; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; F8Q427; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008063};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1367..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1416..1436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..707
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 733..1364
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1474 AA; 165663 MW; C55690ACADFEF341 CRC64;
MSAPKKEQSG CGWSHTSEGI RLNGAARGTE YAQDPKHDVS YFDNSPAQLF FFDDTSSAVL
HDVAEGNIYV SQDEGKSWER ASDIPTGAAG MLIEHPFENH YAFVLTGGTT HYRTDDRGRT
WRQFEVPAAV SFIGNPLSFH SDPAKWGHII YHGTVCERVG WGETCQDNAF YTTDAFDTTP
KTLRPDITRC QYAHSSKDFK HDANENLIYC VGFDAASATG SHSLSSSRLF SSTDYFQSEN
KIEDLGIGRN ARGVMAFAIV SKFAVVALKD LSPGNNGDML LYVTVNTREW AQAHFPHASS
ARLRENAYTI VESTIHSLAV DVMLQDQSTI GTLFVSNSNG TFFVESLKDT NRNEFGFVDF
ETIYGVEGVG ISNIIVNAQD VERQRAPKRL RSMITLDDGS SWSPIRAPST DFDGARIKCD
PSDSDQCSLH LHSVTNSHNY GRIFSSPAPG LVMGVGSIGP YLLPYEECDT FLSIDAGLSW
NMIRRDAHKY EFGDQGSIIV AVNDEESTNS VKYSTDMGKN WKTYDFGINL RARGLTTVSD
STSQKFILVG QVSRQDQKSD QGRYAIVFLD FAATRNRKCS DDDFEKWYAR SARDKECLMG
HKQWYRRRKP DANCYVGEKF NDPVEHEENC ACEDADFECD YNFVRSGDKC VPSGPESIPS
TQCTTGNPTE SYLGSSGYRL IPGNTCDRSR GIKKDEPVSK KCSEAQPAEG EIINQIFEFP
AQIIQHHYFK QSSTILVRLS DYSVWQSSNE GYSWDQLFEG ERFLAIYMHT HSSDRAYLLT
DSRKFFYTTD TGRSWNQLNA PSPPNFFHAE VIRFQPRSDY IIWTGNVGCE GMGDHCHAEA
QYSWNNGRDW KFVENYVVNC QWARDSELLI DPTQIMCESY LNKQGSQRFF GRNNPLQLIS
GTDYFSQKTK LFDRVVGFTK FSEFLIVAED LPATNSLDLQ VSLDGRTFAA GQFPQGMHPE
THTYTILESS TMSIFLHMTM TTGPSPPWGN ILKSNSNGTY FGLSLDNVNR NNDGYVDFEK
LIGLDGIAIV NIVANPQEAT ISGRKLLQTR ITHNDGGSWR PLSPPPSDSV GQKYDCTSTS
CALHIHGYTE RPDARATYSS PSVVGVVMAV GNVGEVLAPY TDSDTFLSRD GGFTWEEVHK
DAHLWEFGDS GSIIVIVNDE EPTDHVLFTI DEGITWRQYQ FSQEKIRIRS IVTVPEDTSR
KFTLLGQSPR SPSSSIVIHI DFTSLTHKQC TLNIEDPGHD DFELWSPSEE RNEACLFGRQ
TLYHRRVRNT NCAVGHQPKA EEKIVRYCAC TQEDFECEFN YVRNTAGECV LASGMQPLAD
DDTCRGDDDY WYERTAYRKI FYSSCEGGQR LDRGTRHLCP GVKGHSAWFW FFVLIFPFGI
TALIAFWWYR NSGRARGTIR LPGDYQAMYR SASGSGALST LASVPWFLLG LAGIAWEYVA
STAESMSLGF RSRRGYRDIP VDEDAQILRF EDEE
//
