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Database: UniProt
Entry: F8Q6P6_SERL3
LinkDB: F8Q6P6_SERL3
Original site: F8Q6P6_SERL3 
ID   F8Q6P6_SERL3            Unreviewed;       869 AA.
AC   F8Q6P6;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   07-SEP-2016, entry version 13.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=SERLA73DRAFT_76263 {ECO:0000313|EMBL:EGN96284.1};
OS   Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Boletales; Coniophorineae;
OC   Serpulaceae; Serpula.
OX   NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN   [1] {ECO:0000313|Proteomes:UP000008063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX   PubMed=21764756; DOI=10.1126/science.1205411;
RA   Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA   Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M.,
RA   Blumentritt M., Coutinho P.M., Cullen D., de Vries R.P., Gathman A.,
RA   Goodell B., Henrissat B., Ihrmark K., Kauserud H., Kohler A.,
RA   LaButti K., Lapidus A., Lavin J.L., Lee Y.-H., Lindquist E., Lilly W.,
RA   Lucas S., Morin E., Murat C., Oguiza J.A., Park J., Pisabarro A.G.,
RA   Riley R., Rosling A., Salamov A., Schmidt O., Schmutz J., Skrede I.,
RA   Stenlid J., Wiebenga A., Xie X., Kuees U., Hibbett D.S.,
RA   Hoffmeister D., Hoegberg N., Martin F., Grigoriev I.V.,
RA   Watkinson S.C.;
RT   "The plant cell wall-decomposing machinery underlies the functional
RT   diversity of forest fungi.";
RL   Science 333:762-765(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GL945484; EGN96284.1; -; Genomic_DNA.
DR   EnsemblFungi; EGN96284; EGN96284; SERLA73DRAFT_76263.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000008063; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008063};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008063};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    414    443       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    464    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    559       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    580    599       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    656       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    771    794       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      105    132       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   869 AA;  99014 MW;  34A08842A5D40D4E CRC64;
     MGDEYPTLFR SEQMSLVQLY VPTEVAHDTT AELGERGNVQ FKDLNPNVTP FQRSFVGEIR
     RIEDMARRVR FFSSQIEMEK DVIPIRPLYD CAPLITVGPR AAQTMDELNV TLAEHESRLL
     RMNDSYKNFS EKTKELVEAR HVLRETAVFF QRAEDQHADI RTSYDDSSAP LLQHDDSENQ
     YSAPVQFDLE FVAGTIDRTR ISTFERVLWR VLRGNLYMNH TDIAEPFLDP ATGAETRKNV
     FIIFAHGEVL LAKIRKVAES MGATIYPIDA NADKRSDSLR EVTARLEDLQ TVLYNTGMNR
     RSQLVTIGES LASWQDVVKK EKLIYETMNL FNYDVRRKTL VAEGWCPTRD ITEIQMALRR
     ATEDSGTSVV PILQELRTNK ASPTYNRTNK FTEGFQSIMD SYGIASYQEV NPGLFAVITF
     PFLFAVMFGD IGHGFIIFLA ALYMIIKERQ WAKADLGEII GQFFYGRYII LMMGLFSMYT
     GLMYNDIFSK SLHIWHSGWD FPEGNGTVVA VSNGHVYPFG LDPGWHGADN GLVFTNSYKM
     KMSVVLGVIH MTFALCLQVP NHIRFKRSFD IVTNFIPQMI FLQSIFGYLV VCILYKWSID
     WSTRSTEPPS LLNMLIAMFL SPGTIDPQTQ LYPGQGFIQV VLVLLAMICV PWMLCMKPYL
     QWKEMKKIQG QGYVGLGQHD GMPRDSSDDV LEGEEEGNGR AVVEEMDEEH EHHDFGEVVI
     HQVIHTIEFC LGCISHTASY LRLWALSLAH AQLSEVLWDM TLAGFLEPSG ITGIIALVVM
     VVFWFSLTVF ILCVMEGLSA FLHAVRLHWV EANSKHYEGG GYVSDTLQRP VRGFFDTNIF
     ERGIRMLMVY PLIQAFTPLS FAKLDEKDS
//
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