ID F8QAY3_SERL3 Unreviewed; 763 AA.
AC F8QAY3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0000259|PROSITE:PS00623, ECO:0000259|PROSITE:PS00624};
GN ORFNames=SERLA73DRAFT_171373 {ECO:0000313|EMBL:EGN94369.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|RuleBase:RU003968}.
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DR EMBL; GL945488; EGN94369.1; -; Genomic_DNA.
DR AlphaFoldDB; F8QAY3; -.
DR STRING; 936435.F8QAY3; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_011025_0_0_1; -.
DR InParanoid; F8QAY3; -.
DR OMA; IGYLQCA; -.
DR OrthoDB; 52047at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR CDD; cd09630; CDH_like_cytochrome; 1.
DR Gene3D; 2.60.40.1210; Cellobiose dehydrogenase, cytochrome domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR015920; Cellobiose_DH_cyt.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR47190:SF2; CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620); 1.
DR PANTHER; PTHR47190; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF16010; CDH-cyt; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR SMART; SM00664; DoH; 1.
DR SUPFAM; SSF49344; CBD9-like; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU003968};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003968};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008063};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..763
FT /note="Glucose-methanol-choline oxidoreductase N-terminal
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003377245"
FT DOMAIN 312..335
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 480..494
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
SQ SEQUENCE 763 AA; 80943 MW; DA4E2A8A021FAE75 CRC64;
MVLSFLLLSV LSISGSVLAQ SSSGYTDSGN GFVFQGYTDP VYDVTYGLVF PPLVTTGTNS
TEFIGEIVAP IGAQWIGLSL GGAMLDSLLL VAWPNINSVV FSSRYTTAYT GPIITSLPST
TVNSTHWKWV FRCQNCTSWQ GGSINLGGSS ALAWAYSNVA VNDPSDPQSS FQEHTDFGFF
GENFAAAHSS NYNNYLNGDP GTTSSVPTST STVVSSTTTL TSPTTTATPY DYIVVGAGPG
GIIAADRLSE AGKKVLLLER GGPSTGETGG TYDAVWAEGT NLTKFDIPGL FESMFTDSNP
WYWCKDITVF AGCLLGGGTS INGALYWLPQ DSDFSTSVGW PSSWGNHQPY TNKMAARLPS
TDHPSTDGLR YLEQSATVTA QLLNGQGYRN ITINDDPNSK DHSYGNSAFD FINGKRGGPV
ATYLQTALAR SNFVYKDHTL VSNVVRNGSQ ITGVQTNDSS LGPNGVVPLT PNGRVILSAG
SYGSPRILFQ SGIGPADMIA LVEGSPTAAA NLPPSSQYID LPVGYNVSDN PSINFVFTHP
SIDAYDNWAD VWTDPRPADA VQYLKDQSGV FAGASPKLNF WRSYTGTDDK QRWMQGTVRP
GASAVNTTYA YNDSQIFTIT TYLSQGVTSR GRIGINAALT GLPLVNPWFT DPVDKSTLIT
ALNDIVSNIN TVPGLTLITP DNQTTITDYV NSYDPGSLDS NHWVGSNSIG SVVDSNTKVF
STNNLFVVDA SIIPSLPTGN PHGTLMSAAE QAAAKILALA GGP
//
