ID F8QMD6_TOXGO Unreviewed; 554 AA.
AC F8QMD6;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=rop18 {ECO:0000313|EMBL:ADH04610.1};
OS Toxoplasma gondii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=5811 {ECO:0000313|EMBL:ADH04610.1};
RN [1] {ECO:0000313|EMBL:ADH04610.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=QHO {ECO:0000313|EMBL:ADH04610.1};
RA Liu M., Peng G., Yuan Z., He X., Zhu X.;
RT "Genetic variation and phylogenetic relationship of Toxoplasma gondii
RT isolated from Guangzhou in mainland China based on rop16 and rop18 genes.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; GQ243205; ADH04610.1; -; Genomic_DNA.
DR AlphaFoldDB; F8QMD6; -.
DR VEuPathDB; ToxoDB:TGARI_205250; -.
DR VEuPathDB; ToxoDB:TGCOUG_205250; -.
DR VEuPathDB; ToxoDB:TGDOM2_205250; -.
DR VEuPathDB; ToxoDB:TGMAS_205250; -.
DR VEuPathDB; ToxoDB:TGME49_205250; -.
DR VEuPathDB; ToxoDB:TGP89_205250; -.
DR VEuPathDB; ToxoDB:TGPRC2_205250; -.
DR VEuPathDB; ToxoDB:TGVEG_205250; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027916; Kinase-like_dom_Apicomplexa.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24349:SF569; MAP KINASE-ACTIVATED PROTEIN KINASE 2; 1.
DR PANTHER; PTHR24349; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF14531; Kinase-like; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..531
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 281
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 554 AA; 62637 MW; C038ACBF64B44E0C CRC64;
MFSVQRPPLT RTVVRMGLAT LLPKTACLAV LNVALVFLLF QVQDGTGITL DPSKLDSKPT
SLDSQQHVAD KRWPATAGHY KYLAGATEST RDVSLLEERA QHRVNAQETN QRRTIFQRLL
NLLRRRERDG EVSGSAADSS SRPRLSVRQR LAQLWRKAKS FFTRGIPRYF SQGRNRLRSL
RAQRRRSELF FEKADSGCVI GKRILAHMQE QIGQPQALGN SERLDRILTV AAWPPDVPER
FVSVTTGETR TLVRGAPLGS GGFATVYEAT DVETNEELAV KVFMSEKEPT DETMRDLQRE
SFCYRNFSLA KTAKDAQERC RFMVPSDVVM LEGQPASTEV VIGLTTRWVP NYFLLMMRAE
TDMSKVISWV FGDASVNNSE LGLVVRMYLS SQAIRLVANV QAQGIVHTDI KPANFLLLKD
GRLFLGDFGT YRINNSVGPA IGTPGYEPPE RPFQTTDITY TFTTDAWQLG ITLYCIWCKE
RPTPADGIWD YLHFADCPST PELVQDLIRN LLNREPQKRM LPLQALETAA FNEMDSVVKR
AAQNFEQQEH LHTE
//