ID F8RC52_HPV56 Unreviewed; 155 AA.
AC F8RC52;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Protein E6 {ECO:0000256|RuleBase:RU363123};
DE Flags: Fragment;
GN Name=E6 {ECO:0000313|EMBL:AEI54139.1};
OS Human papillomavirus 56.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Alphapapillomavirus; Alphapapillomavirus 6.
OX NCBI_TaxID=10596 {ECO:0000313|EMBL:AEI54139.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AEI54139.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bsb-26 {ECO:0000313|EMBL:AEI54139.1};
RX PubMed=21270605; DOI=10.1097/IGC.0b013e318208c73d;
RA Wyant P.S., Cerqueira D.M., Moraes D.S., Leite J.P., Martins C.R.,
RA de Macedo Brigido M., Raiol T.;
RT "Phylogeny and polymorphism in the long control region, E6, and L1 of human
RT papillomavirus types 53, 56, and 66 in central Brazil.";
RL Int. J. Gynecol. Cancer 21:222-229(2011).
CC -!- FUNCTION: Plays a major role in the induction and maintenance of
CC cellular transformation. {ECO:0000256|RuleBase:RU363123}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|RuleBase:RU363123}.
CC Host nucleus {ECO:0000256|RuleBase:RU363123}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC {ECO:0000256|ARBA:ARBA00006346, ECO:0000256|RuleBase:RU363123}.
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DR EMBL; HM585461; AEI54139.1; -; Genomic_DNA.
DR SMR; F8RC52; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.240.40; E6 early regulatory protein; 2.
DR HAMAP; MF_04006; HPV_E6; 1.
DR InterPro; IPR001334; E6.
DR InterPro; IPR038575; E6_sf.
DR Pfam; PF00518; E6; 1.
DR SUPFAM; SSF161229; E6 C-terminal domain-like; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU363123};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU363123};
KW Early protein {ECO:0000256|ARBA:ARBA00022518,
KW ECO:0000256|RuleBase:RU363123};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host nucleus {ECO:0000256|RuleBase:RU363123};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU363123};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU363123};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU363123};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU363123};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU363123}.
FT NON_TER 155
FT /evidence="ECO:0000313|EMBL:AEI54139.1"
SQ SEQUENCE 155 AA; 18579 MW; 87526C58A3FCD24D CRC64;
MEPQFNNPQE RPRRLHHLSE VLEIPLIDLR LSCVYCKKEL TRAEVYNFAC TELNLVYRDD
FPYAVCRVCL LFYSKVRKYR YYDYSVYGAT LESITKKQLC DLLIRCYRCQ SPLTPEEKQL
HCDRKRRFHL IAHGWTGSCL GCWRQTSREP RESTV
//
