ID F8RDX0_HHV1 Unreviewed; 206 AA.
AC F8RDX0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Envelope glycoprotein I {ECO:0000256|ARBA:ARBA00013983};
DE Flags: Fragment;
GN Name=US7 {ECO:0000313|EMBL:ADM22927.1};
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:ADM22927.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADM22927.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E15 {ECO:0000313|EMBL:ADM22927.1};
RX PubMed=22417106; DOI=10.1111/j.1749-6632.2011.06358.x;
RA Davison A.J.;
RT "Evolution of sexually transmitted and sexually transmissible human
RT herpesviruses.";
RL Ann. N. Y. Acad. Sci. 1230:E37-E49(2011).
RN [2] {ECO:0000313|EMBL:ADM22927.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E15 {ECO:0000313|EMBL:ADM22927.1};
RA Davison A.J.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In epithelial cells, the heterodimer gE/gI is required for
CC the cell-to-cell spread of the virus, by sorting nascent virions to
CC cell junctions. Once the virus reaches the cell junctions, virus
CC particles can spread to adjacent cells extremely rapidly through
CC interactions with cellular receptors that accumulate at these
CC junctions. Implicated in basolateral spread in polarized cells. In
CC neuronal cells, gE/gI is essential for the anterograde spread of the
CC infection throughout the host nervous system. Together with US9, the
CC heterodimer gE/gI is involved in the sorting and transport of viral
CC structural components toward axon tips.
CC {ECO:0000256|ARBA:ARBA00025134}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Host cell junction {ECO:0000256|ARBA:ARBA00004315}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004381}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004381}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein I family.
CC {ECO:0000256|ARBA:ARBA00005825}.
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DR EMBL; HM585503; ADM22927.1; -; Genomic_DNA.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR002874; Herpes_gI.
DR Pfam; PF01688; Herpes_gI; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Viral envelope protein {ECO:0000313|EMBL:ADM22927.1};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT NON_TER 206
FT /evidence="ECO:0000313|EMBL:ADM22927.1"
SQ SEQUENCE 206 AA; 22001 MW; 9DCCCD2DEDB31CB3 CRC64;
MPCRPLQGLV LVGLWVCATS LVVRGPTVSL VSNSFVDAGA LGPHGVVEED LLILGELRFV
GDQVPHTTYY DGVVELWHYP MGHKCPRVVH VVTVTACPRR PAVAFALCRA TDSTHSPAYP
TLDLNLAQQP LLRVRRATRD YAGVYVLRVW VGDAPNASLF VLGMAIAAEG TLAYNGSAHG
SCDPKLLPSS APRLAPASVY QPAPNP
//
