ID F8RP77_EPICO Unreviewed; 253 AA.
AC F8RP77;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 22-FEB-2023, entry version 37.
DE RecName: Full=Lymphotoxin-alpha {ECO:0000256|ARBA:ARBA00018403};
DE AltName: Full=TNF-beta {ECO:0000256|ARBA:ARBA00033253};
DE AltName: Full=Tumor necrosis factor ligand superfamily member 1 {ECO:0000256|ARBA:ARBA00033263};
OS Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Serranoidei; Serranidae; Epinephelinae;
OC Epinephelini; Epinephelus.
OX NCBI_TaxID=94232 {ECO:0000313|EMBL:AEH59794.1};
RN [1] {ECO:0000313|EMBL:AEH59794.1}
RP NUCLEOTIDE SEQUENCE.
RA Lam F.W.S., Lin S.J., Wu S.Y., Lin J.H.Y.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEH59794.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21195186; DOI=10.1016/j.fsi.2010.12.011;
RA Lam F.W., Wu S.Y., Lin S.J., Lin C.C., Chen Y.M., Wang H.C., Chen T.Y.,
RA Lin H.T., Lin J.H.;
RT "The expression of two novel orange-spotted grouper (Epinephelus coioides)
RT TNF genes in peripheral blood leukocytes, various organs, and fish
RT larvae.";
RL Fish Shellfish Immunol. 30:618-629(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; HQ011925; AEH59794.1; -; mRNA.
DR AlphaFoldDB; F8RP77; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002960; TNF_beta.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF31; LYMPHOTOXIN-ALPHA; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01236; TNFBETA.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..253
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 253 AA; 27895 MW; 0C0EC0A5C0A45F2E CRC64;
MVAYTTAPGD VEMGPEERTV VLVEKKSSAV QIWKVSVALL TVALCIGGVL LFAWYWSGKP
DITTQSGQRE ALIKSDTAEK TDPHYNLSRI SSKAKAAIHL EGNYEDCESS KHQLEWRNGQ
GQAFAQGGFK LVKNQIIIPQ TGLYFVYSQA SFRVSCSDGD EKGAGRRLMP LSHRIWRYSD
SIGSKASLMS AVRSACQSTA QEDSDGSGKG WYNAIYLGAV FQLNKGDRLW TETNQLSELE
TDEGRTFFGV FAL
//
