ID   F8SNA2_9SAUR            Unreviewed;       218 AA.
AC   F8SNA2;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AEH25691.1};
OS   Prasinohaema virens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Scinciformata; Scincidae;
OC   Sphenomorphinae; Prasinohaema.
OX   NCBI_TaxID=220792 {ECO:0000313|EMBL:AEH25691.1};
RN   [1] {ECO:0000313|EMBL:AEH25691.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Skinner A., Hugall A.F., Hutchinson M.N.;
RT   "Lygosomine phylogeny and the origins of Australian scincid lizards.";
RL   J. Biogeogr. 38:1044-1058(2011).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; HQ655184; AEH25691.1; -; Genomic_DNA.
DR   AlphaFoldDB; F8SNA2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          125..218
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEH25691.1"
FT   NON_TER         218
FT                   /evidence="ECO:0000313|EMBL:AEH25691.1"
SQ   SEQUENCE   218 AA;  24493 MW;  95C94D392BDD08AD CRC64;
     MVISYFSCMK AAPMKEVSLR GQGSLAYPGL RTQGTLENLG GPNDASRGLT SLADTFEHVI
     KELLDEQQVI QPSKENKDAD LYSSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR
     HSDPARRGEL SVCDSTSEWV TAAEKKTAVD MSGATVTVLE KVPVPKGQLK QYFYETKCNS
     KGYTKEGCRG IDKRYWNSQC RTTQSYVRAL TMDNKKRV
//