ID F8STJ7_ICTPU Unreviewed; 905 AA.
AC F8STJ7;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=TLR3 {ECO:0000313|EMBL:AEI59664.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AEI59664.1};
RN [1] {ECO:0000313|EMBL:AEI59664.1}
RP NUCLEOTIDE SEQUENCE.
RA Quiniou S.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEI59664.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23558557;
RA Quiniou S.M., Boudinot P., Bengten E.;
RT "Comprehensive survey and genomic characterization of Toll-like receptors
RT (TLRs) in channel catfish, Ictalurus punctatus: identification of novel
RT fish TLRs.";
RL Immunogenetics 65:511-530(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; HQ677715; AEI59664.1; -; Genomic_DNA.
DR AlphaFoldDB; F8STJ7; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF13676; TIR_2; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..905
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003384311"
FT TRANSMEM 704..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 757..898
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 905 AA; 103619 MW; 5D4FC7F9B230A3A5 CRC64;
MAIWNTTLPL LFLCTWVLVP SRAYRSECRV ELRKADCSHM NLNTIPQDLP EDISVLDVSH
NRLVELKPSS LTRYRSLEHI DASYNSLKAV PAGLCQATPE LWWLTLRHNE VHLLQDRDLR
NCTRLTHLDL SDNRLRLTGE PFSGTENLAF LDVSRNKLTT ARLGSRPQLP SLQTLVVAGN
DIADLKKDDF YFLNESSLFR TLSLSSLPLK KVDRGCFKPI AGLQDLVLDG CKLNPSFMSR
LCEELSDTSL RNLSIQFTQQ VMLNNSTFKG LGKTNLTILD LSNNNMARIT DGAFQWFPML
EYLSLEHNNL KHLTKGTFLG LKSLRKLNLQ SALAKGHASP LPVIDDFSFQ PLVKLEYLYM
EKTSFREITE NIFYGLPCLR ELNLGWSSTG LKIVSNTTFA SLNGSSLLQM LNLTGMGIKT
LEPGAFSSLG NLEILVLSHN YINQQLTGEE FQGLNSIREI HLSFNQQMIT LMSTSFIHVP
TLRTLMLGHA LSSNLEVEPS PFRLLVNLTL LDLSNNNIAN IKNGLLDGLH HLSVLKLQHN
NLARVWKNAN PGGPVLILRD AQNLTVLELD YNGLDEIPMK AFQGLSKLKY LSISGNLLNF
LHDSIFDNLR SLRFLRLQKN LLTSVRRETF GVPLSNLTEL FMDHNPFDCT CESILWFNKW
LNTTNTSVPD RAKSYVCNTP SMYFNRSVLD FNPESCKDLV PFQALYVITS SLVLGLMVLA
FLVHFQGWRI QFYWNILVNR TLDINDSRYK RVAECRYEYK AYVVHAQEDR LWVERSLLPL
EDKDFRFFLE DRDAMPGSSR LETIVDNMRI SRKILFVVTE ALLNDPWCRQ FKVHHALHQL
MEENRDSLVL IFLEDVADYR LTQSLMLRKG MLKHRCMLQW PLQKERIPAF RQKLQLALAS
SNRVS
//
