ID F8UJD1_UTAST Unreviewed; 196 AA.
AC F8UJD1;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|EMBL:AEI16882.1};
DE Flags: Fragment;
GN Name=BMP2 {ECO:0000313|EMBL:AEI16882.1};
OS Uta stansburiana (Side-blotched lizard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Phrynosomatidae; Phrynosomatinae; Uta.
OX NCBI_TaxID=43653 {ECO:0000313|EMBL:AEI16882.1};
RN [1] {ECO:0000313|EMBL:AEI16882.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21787873; DOI=10.1016/j.ympev.2011.07.008;
RA Townsend T.M., Mulcahy D.G., Noonan B.P., Sites J.W.Jr., Kuczynski C.A.,
RA Wiens J.J., Reeder T.W.;
RT "Phylogeny of iguanian lizards inferred from 29 nuclear loci, and a
RT comparison of concatenated and species-tree approaches for an ancient,
RT rapid radiation.";
RL Mol. Phylogenet. Evol. 61:363-380(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JF806075; AEI16882.1; -; Genomic_DNA.
DR AlphaFoldDB; F8UJD1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 103..196
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 95..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..115
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEI16882.1"
FT NON_TER 196
FT /evidence="ECO:0000313|EMBL:AEI16882.1"
SQ SEQUENCE 196 AA; 22383 MW; 93E59B0DDBC1DB87 CRC64;
IKPEGEASKD PVTRLLDTRL IHHNASKWET FDVTPAIRRW VAHGQPNHGF VVEVVHLDNK
SSVSKRHVRI SRSLHQDDGS WSQIRPLLVT FGHDGKGHPL HRREKRQAKY KERKRHKSHC
KRHPLYVDFN DVGWNDWIVA PPGYSAFHCR GDCPFPLADH LNSTNHAIVQ TLVNSVNSKI
PKACCVPTEL SPISML
//
