ID F8WGM5_MOUSE Unreviewed; 594 AA.
AC F8WGM5;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Syntaxin-binding protein 2 {ECO:0000256|ARBA:ARBA00040518};
DE AltName: Full=Protein unc-18 homolog 2 {ECO:0000256|ARBA:ARBA00042595};
DE AltName: Full=Protein unc-18 homolog B {ECO:0000256|ARBA:ARBA00042592};
DE Flags: Fragment;
GN Name=Stxbp2 {ECO:0000313|Ensembl:ENSMUSP00000004745.9,
GN ECO:0000313|MGI:MGI:107370};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000004745.9, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000004745.9, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000004745.9,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000004745.9}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000004745.9};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family.
CC {ECO:0000256|ARBA:ARBA00009884}.
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DR SwissPalm; F8WGM5; -.
DR jPOST; F8WGM5; -.
DR MaxQB; F8WGM5; -.
DR PeptideAtlas; F8WGM5; -.
DR ProteomicsDB; 315965; -.
DR Antibodypedia; 2787; 244 antibodies from 29 providers.
DR Ensembl; ENSMUST00000004745.9; ENSMUSP00000004745.9; ENSMUSG00000004626.15.
DR AGR; MGI:107370; -.
DR MGI; MGI:107370; Stxbp2.
DR VEuPathDB; HostDB:ENSMUSG00000004626; -.
DR GeneTree; ENSGT00940000160045; -.
DR PhylomeDB; F8WGM5; -.
DR ChiTaRS; Stxbp2; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000004626; Expressed in granulocyte and 209 other cell types or tissues.
DR ExpressionAtlas; F8WGM5; baseline and differential.
DR GO; GO:0042582; C:azurophil granule; IEA:Ensembl.
DR GO; GO:0044194; C:cytolytic granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042581; C:specific granule; IEA:Ensembl.
DR GO; GO:0070820; C:tertiary granule; IEA:Ensembl.
DR GO; GO:0030348; F:syntaxin-3 binding; IEA:Ensembl.
DR GO; GO:0001909; P:leukocyte mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0043312; P:neutrophil degranulation; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.60; -; 1.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679:SF27; SYNTAXIN-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR11679; VESICLE PROTEIN SORTING-ASSOCIATED; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; Sec1/munc18-like (SM) proteins; 1.
PE 1: Evidence at protein level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|EPD:F8WGM5,
KW ECO:0007829|MaxQB:F8WGM5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000004745.9"
SQ SEQUENCE 594 AA; 66425 MW; 9DAF9DDEB7FFD2E8 CRC64;
XAPLGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED
INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR
SRLAKAVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD ALAQQIATLC
ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV
SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS
VEKLCSVEQD LAMGSDAEGE KIKDAMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE
NLAKLIQHAN VQSYSSLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK
DVMEDVVEDR LDRKLWPFVS DPAPVPSSQA AVSSARFGHW HKNKAGVEAR AGPRLIVYIV
GGVAMSEMRA AYEVTRATEG KWEVLIGSSH ILTPTRFLDD LKTLDQKLEG VALP
//
