ID F8WKF1_STAAU Unreviewed; 442 AA.
AC F8WKF1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Metallo-beta-lactamase {ECO:0000313|EMBL:BAK53130.1, ECO:0000313|EMBL:CAC8488472.1};
DE EC=3.-.-.- {ECO:0000313|EMBL:CAC8488472.1};
DE SubName: Full=Persulfide dioxygenase-sulfurtransferase CstB {ECO:0000313|EMBL:MVI54775.1};
GN Name=cstB {ECO:0000313|EMBL:MVI54775.1};
GN Synonyms=pksB {ECO:0000313|EMBL:CAC8488472.1};
GN ORFNames=BN1321_20008 {ECO:0000313|EMBL:CRI08687.1}, GO793_02740
GN {ECO:0000313|EMBL:MVI54775.1}, GO941_15890
GN {ECO:0000313|EMBL:MVL46919.1}, SAMEA70245418_00013
GN {ECO:0000313|EMBL:CAC8488472.1};
OS Staphylococcus aureus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:BAK53130.1};
RN [1] {ECO:0000313|EMBL:BAK53130.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCSC6944 {ECO:0000313|EMBL:BAK53130.1};
RX PubMed=21422209; DOI=10.1128/AAC.01475-10;
RA Li S., Skov R.L., Han X., Larsen A.R., Larsen J., Sorum M., Wulf M.,
RA Voss A., Hiramatsu K., Ito T.;
RT "Novel types of staphylococcal cassette chromosome mec elements identified
RT in clonal complex 398 methicillin-resistant Staphylococcus aureus
RT strains.";
RL Antimicrob. Agents Chemother. 55:3046-3050(2011).
RN [2] {ECO:0000313|EMBL:AGX31704.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MRSA P126 {ECO:0000313|EMBL:AGY50275.1}, and MSSA P211
RC {ECO:0000313|EMBL:AGX31704.1};
RX PubMed=24072172; DOI=10.1093/jac/dkt366;
RA Vandendriessche S., Vanderhaeghen W., Larsen J., de Mendonca R., Hallin M.,
RA Butaye P., Hermans K., Haesebrouck F., Denis O.;
RT "High genetic diversity of methicillin-susceptible Staphylococcus aureus
RT (MSSA) from humans and animals on livestock farms and presence of SCCmec
RT remnant DNA in MSSA CC398.";
RL J. Antimicrob. Chemother. 69:355-362(2014).
RN [3] {ECO:0000313|EMBL:CRI08687.1, ECO:0000313|Proteomes:UP000039437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AH1 {ECO:0000313|EMBL:CRI08687.1,
RC ECO:0000313|Proteomes:UP000039437};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000433366, ECO:0000313|Proteomes:UP000434412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S_2023.LVRQ.AN {ECO:0000313|EMBL:MVL46919.1,
RC ECO:0000313|Proteomes:UP000434412}, and S_4031.LGMP.AI
RC {ECO:0000313|EMBL:MVI54775.1, ECO:0000313|Proteomes:UP000433366};
RA Stine O.C.;
RT "Implementation of targeted gown and glove precautions to prevent
RT Staphylococcus aureus acquisition in community-based nursing homes.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:CAC8488472.1, ECO:0000313|Proteomes:UP000507408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MOS222 {ECO:0000313|EMBL:CAC8488472.1,
RC ECO:0000313|Proteomes:UP000507408};
RG Pathogen Informatics;
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KF593810; AGX31704.1; -; Genomic_DNA.
DR EMBL; KF593809; AGY50275.1; -; Genomic_DNA.
DR EMBL; AB505629; BAK53130.1; -; Genomic_DNA.
DR EMBL; CAIIKR010000001; CAC8488472.1; -; Genomic_DNA.
DR EMBL; CVOQ01000012; CRI08687.1; -; Genomic_DNA.
DR EMBL; WPRH01000199; MVI54775.1; -; Genomic_DNA.
DR EMBL; WPVZ01000858; MVL46919.1; -; Genomic_DNA.
DR RefSeq; WP_016187232.1; NZ_VRRY01000039.1.
DR PATRIC; fig|1280.3385.peg.1731; -.
DR Proteomes; UP000039437; Unassembled WGS sequence.
DR Proteomes; UP000433366; Unassembled WGS sequence.
DR Proteomes; UP000434412; Unassembled WGS sequence.
DR Proteomes; UP000507408; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050313; F:sulfur dioxygenase activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd07724; POD-like_MBL-fold; 1.
DR CDD; cd00158; RHOD; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 2.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR044528; POD-like_MBL-fold.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR43084; PERSULFIDE DIOXYGENASE ETHE1; 1.
DR PANTHER; PTHR43084:SF1; PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 2.
DR PROSITE; PS50206; RHODANESE_3; 2.
PE 4: Predicted;
KW Dioxygenase {ECO:0000313|EMBL:MVI54775.1};
KW Hydrolase {ECO:0000313|EMBL:CAC8488472.1};
KW Oxidoreductase {ECO:0000313|EMBL:MVI54775.1};
KW Transferase {ECO:0000313|EMBL:MVI54775.1}.
FT DOMAIN 277..345
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 360..436
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
SQ SEQUENCE 442 AA; 49376 MW; 6D92B0667B41AE62 CRC64;
MFFKQFYDKH LSQASYLIGC QKTGEAMIID PIRDLSSYIR VADEEGLTIT HAAETHIHAD
FASGIRDVAI KLNANIYVSG ESDDTLGYKN MPNHTYFVQH NDDIYVGNIK LKVLHTPGHT
PESISFLLTD EGAGAQVPMG LFSGDFIFVG DIGRPDLLEK AVKVEGSSEI GAKQMFKSIE
SIKDLPDYIQ IWPGHGAGSP CGKSLGAIPT STLGYEKQTN WAFSENNEAT FIDKLISDQP
APPHHFAQMK KINQFGMNLY QPYTVYPATN TNRLTFDLRS KEAYHGGHIE GTINIPYDKN
FINQIGWYLN YDQEINLIGD YHLVSKATHT LQLIGYDDVA GYQLPQSKVQ TRSIHSEDIT
GNESHILDVR NDNEWNNGHL SQAVHVPHGK LLDTDLPFSK NDVIYVHCQS GIRSSIAIGI
LEHKGYHNII NVNEGYKDIH LS
//
