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Database: UniProt
Entry: F8WR14_9EUKA
LinkDB: F8WR14_9EUKA
Original site: F8WR14_9EUKA 
ID   F8WR14_9EUKA            Unreviewed;       404 AA.
AC   F8WR14;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   22-FEB-2023, entry version 41.
DE   RecName: Full=Tubulin beta chain {ECO:0000256|RuleBase:RU000352};
DE   Flags: Fragment;
GN   Name=TUB1 {ECO:0000313|EMBL:BAK61740.1};
OS   Collozoum amoeboides.
OC   Eukaryota; Sar; Rhizaria; Retaria; Polycystinea; Collodaria; Sphaerozoidae;
OC   Collozoum.
OX   NCBI_TaxID=1041365 {ECO:0000313|EMBL:BAK61740.1};
RN   [1] {ECO:0000313|EMBL:BAK61740.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ishitani Y., Ishikawa S.A., Inagaki Y., Tsuchiya M., Takahashi K.,
RA   Takishita K.;
RT   "Multigene phylogenetic analyses including diverse radiolarian species
RT   support the "Retaria" hypothesis - The sister relationship of Radiolaria
RT   and Foraminifera.";
RL   Mar. Micropaleontol. 81:32-42(2011).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC       consisting of laterally associated linear protofilaments composed of
CC       alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC       of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC       forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC       GTPase activity of alpha-tubulin. {ECO:0000256|RuleBase:RU000352}.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells. {ECO:0000256|RuleBase:RU000352}.
CC   -!- SIMILARITY: Belongs to the tubulin family.
CC       {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR   EMBL; AB613234; BAK61740.1; -; mRNA.
DR   AlphaFoldDB; F8WR14; -.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   CDD; cd02187; beta_tubulin; 1.
DR   Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR   Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR   Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR   InterPro; IPR002453; Beta_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; TUBULIN; 1.
DR   PANTHER; PTHR11588:SF429; TUBULIN BETA-1 CHAIN-RELATED; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01163; BETATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR   SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000352}.
FT   DOMAIN          40..237
FT                   /note="Tubulin/FtsZ GTPase"
FT                   /evidence="ECO:0000259|SMART:SM00864"
FT   DOMAIN          239..376
FT                   /note="Tubulin/FtsZ 2-layer sandwich"
FT                   /evidence="ECO:0000259|SMART:SM00865"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAK61740.1"
FT   NON_TER         404
FT                   /evidence="ECO:0000313|EMBL:BAK61740.1"
SQ   SEQUENCE   404 AA;  45122 MW;  F9770FE6D3D5496E CRC64;
     PAGQCGNQIG AKFWEVISDE HGIDPTGTYH GDSDLQLERI NVYYNEATGG RYVPRAILMD
     LEPGTMDSVR AGPFGQLFRP DNFVFGQTGA GNNWAKGHYT EGAELIDSVL DVVRKEAESC
     DCLQGFQITH SLGGGTGSGM GTLLISKIRE EYPDRMMCTF SIFPSPKVSD TVVEPYNATL
     SVHQLVENAD EVMVIDNEAL YDICFRTLKL TTPTYGDLNH LVSAAMSGIT CCLRFPGQLN
     SDLRKLAVNL IPFPRLHFFM IGFAPLTSRG SQQYRALTVP ELTQQMFDAK NMMCASDPRH
     GRYLTASAMF RGRMSTKEVD EQMLNVQNKN SSYFVEWIPN NIKSSVCDIP PKGLKMSTTF
     IGNTTAIQDM FKRVAEQFTA MFRRKAFLHW YTGEGMDEME FTRG
//
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