ID F9CZ04_9ARCH Unreviewed; 692 AA.
AC F9CZ04;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000256|HAMAP-Rule:MF_00442};
DE EC=5.6.2.4 {ECO:0000256|HAMAP-Rule:MF_00442};
GN Name=hel308 {ECO:0000256|HAMAP-Rule:MF_00442};
GN ORFNames=MY1_0191 {ECO:0000313|EMBL:EGP92972.1};
OS Nitrosarchaeum koreense MY1.
OC Archaea; Nitrososphaerota; Nitrososphaeria; Nitrosopumilales;
OC Nitrosopumilaceae; Nitrosarchaeum.
OX NCBI_TaxID=1001994 {ECO:0000313|EMBL:EGP92972.1, ECO:0000313|Proteomes:UP000004440};
RN [1] {ECO:0000313|EMBL:EGP92972.1, ECO:0000313|Proteomes:UP000004440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MY1 {ECO:0000313|EMBL:EGP92972.1,
RC ECO:0000313|Proteomes:UP000004440};
RX PubMed=21914867; DOI=10.1128/JB.05717-11;
RA Kim B.K., Jung M.Y., Yu D.S., Park S.J., Oh T.K., Rhee S.K., Kim J.F.;
RT "Genome Sequence of an Ammonia-Oxidizing Soil Archaeon, "Candidatus
RT Nitrosoarchaeum koreensis" MY1.";
RL J. Bacteriol. 193:5539-5540(2011).
CC -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC involved in repair of stalled replication forks. {ECO:0000256|HAMAP-
CC Rule:MF_00442}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618, ECO:0000256|HAMAP-
CC Rule:MF_00442};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617, ECO:0000256|HAMAP-
CC Rule:MF_00442};
CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00442}.
CC -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_00442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGP92972.1}.
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DR EMBL; AFPU01000001; EGP92972.1; -; Genomic_DNA.
DR AlphaFoldDB; F9CZ04; -.
DR STRING; 1001994.MY1_0191; -.
DR PATRIC; fig|1001994.6.peg.186; -.
DR Proteomes; UP000004440; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00442; Helicase_Hel308; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048772; Hel308-like_dom4.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR022965; Helicase_Hel308.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961:SF10; ATP-DEPENDENT DNA HELICASE HEL308; 1.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21280; Helicase_dom4_arc; 1.
DR Pfam; PF14520; HHH_5; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00442}; DNA damage {ECO:0000256|HAMAP-Rule:MF_00442};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00442};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00442};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|HAMAP-Rule:MF_00442};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00442};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00442};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00442}.
FT DOMAIN 17..188
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 222..423
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT BINDING 12
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00442"
SQ SEQUENCE 692 AA; 77251 MW; 8CE154D5C0DDA17E CRC64;
MSEGFSKLYP PQADCIDAGL LNGKSILVSA PTASGKTLTA IISMINYLSK NTGKVVYLSP
LRALASEKFT EFKKLEKIDL GKKIRVGIST GDFENIEKNL EKNNILVLTN EKMDSIIRHG
AEWIDEIGLV IADEIHLIGD ESRGPTLEMI LTKLKLLESK PQILGLSATI TNSDELANWL
DCKLVKNDWR PVPLSEGVYD AGGVIMNNGK KFEVEPSIRG IPIDLGVQSV KDGGQSLVFA
ETRTRSKALA TKAADIISQF LEKNESEELE KVSKKILSNN EHTELVKTLA TLIKKGVAFH
HAGLNQNCRQ TIETEFRKGT IKLLSSTPTL AAGVNLPARR VVISNISRYN AKVGANKPIS
ILEYKQLCGR AGRPQYDDYG ESIIVGNGNS EDLMEYYVRG EPEPILSKIT DDKSLRTHVL
SVIVTSPGIK KENILEFFLK TLGGLQSRKA TIKFAIDISL RFLTSAFLII KKGERYAATE
FGKKTSMLYI DPLTATYFRD AIENVSKERK HTFGFLHLIS NCEEFFPKFS LRNKDFETAS
LMIENHSSEI LEPLSEYDCS RSLLALQAWI TESSELSLSD NLGIESGDMH RMVETADWLT
YCLREISKHV ERADLLDELE NLRRRIIYGI KEELLDLVKV KGIGRVRARV LYKHGIKSLD
DLSKIPVNKL AEIDKIGSTI ADNIKSELKK VR
//
