ID F9DV49_9BACL Unreviewed; 449 AA.
AC F9DV49;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 28-MAR-2018, entry version 43.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN ECO:0000313|EMBL:EGQ23370.1};
GN ORFNames=HMPREF9372_2680 {ECO:0000313|EMBL:EGQ23370.1};
OS Sporosarcina newyorkensis 2681.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Planococcaceae;
OC Sporosarcina.
OX NCBI_TaxID=1027292 {ECO:0000313|EMBL:EGQ23370.1, ECO:0000313|Proteomes:UP000005316};
RN [1] {ECO:0000313|EMBL:EGQ23370.1, ECO:0000313|Proteomes:UP000005316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2681 {ECO:0000313|EMBL:EGQ23370.1,
RC ECO:0000313|Proteomes:UP000005316};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z.,
RA Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L.,
RA Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D.,
RA Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R.,
RA San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S.,
RA Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K.,
RA Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation
CC of chromosomal replication. Binds to the origin of replication; it
CC binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|SAAS:SAAS00747961}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC ECO:0000256|SAAS:SAAS00555179}.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:EGQ23370.1}.
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DR EMBL; AFPZ01000084; EGQ23370.1; -; Genomic_DNA.
DR RefSeq; WP_009499369.1; NZ_GL982999.1.
DR STRING; 1027292.HMPREF9372_2680; -.
DR EnsemblBacteria; EGQ23370; EGQ23370; HMPREF9372_2680.
DR eggNOG; ENOG4105CI4; Bacteria.
DR eggNOG; COG0593; LUCA.
DR OrthoDB; POG091H02FF; -.
DR Proteomes; UP000005316; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW Complete proteome {ECO:0000313|Proteomes:UP000005316};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|SAAS:SAAS00747973};
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW Reference proteome {ECO:0000313|Proteomes:UP000005316}.
FT DOMAIN 143 271 AAA. {ECO:0000259|SMART:SM00382}.
FT DOMAIN 356 425 Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT NP_BIND 151 158 ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ SEQUENCE 449 AA; 50667 MW; C8056A61A171DEA9 CRC64;
MENLSNLWDQ VLKNIETRVS KPSFETWLKS TKLLTFEAEN VTIAVPNSFA KDWLETHYVH
LITGILSELT GEDRIIEFIV PQDMVENDIK IPKAPPKVAE KVPMTNSAGM LNPKYTFDTF
VIGSGNRFAH AASLAVAEAP AKAYNPLFIY GGVGLGKTHL MHAIGHYVLE QNPSLKVVYL
SSEKFTNEFI NSIRDNKAGD FRDRYRNVDI LLIDDIQFLA GKEQTQEEFF HTFNTLHEES
KQIIISSDRP PKEIPTLEDR LRSRFEWGLI TDIAPPDLET RIAILRKKAK ADGLIDISND
VMLYIANQID SNIRELEGAL IRVVAYSSLV NADITTDLAA EALKDIIPNS RPRIISILDI
QKSVGEHYNI RLEDFVAKKR TRAIAFPRQI AMFLSRELTD SSLPKIGSEF GGRDHSTVIH
AHEKISKMLE SDKSLQQDIQ DIKKALGRA
//
