ID F9FJM9_FUSOF Unreviewed; 327 AA.
AC F9FJM9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=4-hydroxy-2-oxoglutarate aldolase, mitochondrial {ECO:0008006|Google:ProtNLM};
GN ORFNames=FOXB_06649 {ECO:0000313|EMBL:EGU82846.1};
OS Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660025 {ECO:0000313|EMBL:EGU82846.1};
RN [1] {ECO:0000313|EMBL:EGU82846.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo5176 {ECO:0000313|EMBL:EGU82846.1};
RX PubMed=21942452; DOI=10.1094/mpmi-08-11-0212;
RA Thatcher L.F., Gardiner D.M., Kazan K., Manners J.;
RT "A highly conserved effector in Fusarium oxysporum is required for full
RT virulence on Arabidopsis.";
RL Mol. Plant Microbe Interact. 25:180-190(2012).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGU82846.1}.
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DR EMBL; AFQF01002021; EGU82846.1; -; Genomic_DNA.
DR AlphaFoldDB; F9FJM9; -.
DR STRING; 660025.F9FJM9; -.
DR PaxDb; 5507-FOXG_05126P0; -.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR PANTHER; PTHR12128:SF68; DIHYDRODIPICOLINATE SYNTHETASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365}.
FT ACT_SITE 152
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 181
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 58
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
FT BINDING 226
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 327 AA; 34774 MW; C099F53DF96EBF4D CRC64;
MSAPPPKGIY VPVPTFFASK KTSNYNAITP PIDIETQVAH SVYLAKNGIK GLVVLGSTGE
AVHIHPRDRH AILSGIKAGL EKEGFKDYPI IAGTATNSVE ETVEQLKDAQ KSGSQWGLCL
VPGYNAGAVT QEGIIQWFTA VADQSPIPVM IYHYPGVSNN VKVAPSTYAT LAKHSNIVGC
KLSHGDVSVA AQVASNPSID HTHFHCFTGL GQQLLPVISV GFAGAIDGSA GFFPKSLVRL
FELSSKTQPT DAEIQERRLL QFKVSSMEEL VVKFGTVGIK DAISRLRGFG DTDGTRLPLV
GGIPGGDAEW AKWKGVIGAV DEVEKSL
//
