ID   F9FV19_FUSOF            Unreviewed;      1387 AA.
AC   F9FV19;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Ent-kaurene synthase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=FOXB_10250 {ECO:0000313|EMBL:EGU79219.1};
OS   Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=660025 {ECO:0000313|EMBL:EGU79219.1};
RN   [1] {ECO:0000313|EMBL:EGU79219.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fo5176 {ECO:0000313|EMBL:EGU79219.1};
RX   PubMed=21942452; DOI=10.1094/mpmi-08-11-0212;
RA   Thatcher L.F., Gardiner D.M., Kazan K., Manners J.;
RT   "A highly conserved effector in Fusarium oxysporum is required for full
RT   virulence on Arabidopsis.";
RL   Mol. Plant Microbe Interact. 25:180-190(2012).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|ARBA:ARBA00001971};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGU79219.1}.
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DR   EMBL; AFQF01002705; EGU79219.1; -; Genomic_DNA.
DR   STRING; 660025.F9FV19; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   CDD; cd11041; CYP503A1-like; 1.
DR   Gene3D; 1.50.10.160; -; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR46206; CYTOCHROME P450; 1.
DR   PANTHER; PTHR46206:SF6; CYTOCHROME P450 MONOOXYGENASE GLIF; 1.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
SQ   SEQUENCE   1387 AA;  156009 MW;  9D016A3BE2CA758E CRC64;
     MSSGKIENGT PKDLKTEDEL ISAAKSLLDR AFKSHHSYYG LCSTSCQVYD TAWVAMVSKT
     TDNVKQWLFP ECFHYLLKTQ AADGSWGRLP TTQTAGVLDT ASALLALLSH AREPLQILDV
     SPDELGLRIQ HGVASLKRQL AIWNDVEETN HIGVELIVPA LLSMLEKELG VSSFEFPCRD
     ILDKMHEEKL SHFDLEKVYG KPSSVLHSLE AFLGKIDFDR LSNHLYRGSM MASPSSTAAY
     LIGATKWDDE AEDYLRHVMR DGAGHGDGGI SGTFPTTHFE CSWVLATLLK GGFTVKQIDG
     DALRGLSTIL ADALRDEKGV IGFDIHYGIA PHTADVDDTA KALLALSLVN QPVSPDIMIK
     VFEAKDHFTT FGSERDPSLT SNLHVLLSLL KQPKLSQYHP QILKTTLFIC QRWWGSDHHV
     KDKWNLSHLY PTMLLVEAFT DVLHLVDGGK LSGLFDENLK CKVGLSVFQA VLRIVLNQDD
     DGAWGGYREQ TCYAILALAQ ARHVCFFTHM VDKLQSCIDH GVSWLKSRRL HSQDLTWTSK
     TAYEVGFVAE AYKLAALQSA GLEVPAATVG HSLTSAVPSS DLEQYIRLVR KTALFSSLDD
     WELRASIIES SFFVPLLQAQ RVEIYPRDNI KIEEDRYLSI IPFTWVGCNN RSRAFASNRW
     LYDMMYLSLL GYQTDEYMEA VAGPVFGDIS LLHHTIDKII DNTRLNSAGT NGSVRNGNGH
     QHESPNIRQV EGTLTRFTNS VLKHKDVLRS SSCDQDTLRQ EFRTFMHAHA TQLEDNSRFS
     KQDSGDVFSS PEQSYFQWVN GTGGSHVACA YSFAFSNCLI SANLLQGKDT FPSVTQKYLI
     SSVMRHATNM CRMYNDFGSI ARDNAERNVN SIHFPEFTLC NGMSQSLDER KKRLSQIATY
     EQACLNRALE ALERQSQDDA GDCRGLKEVR KLKIVKLFCD VTDLYDQLYV IKDLSILVSA
     IVPIKVPLPS AFVVFCVQPR RYHPRVAILR SHCSMMNAFI TLIEHLELAG SRALRIVVAS
     AVLWGATGLL ALAWWTCKQL FDEGALPYPV VGDTHAQSFE ENLILGMQKY RDSPFVLAGS
     RPPLLILPMA VFHECHNMPN DRISIIAEHE DKFQGKYTHI TTIRPEIPAT IRQDVTRNMS
     NIILDFQDEL AYASEQWSRT SNWASVPLYK MMLRTIALLS GRAFVGLPLC RDQAWLQASI
     GYTVDCISIR DQLHTWSPIL RPLVGPFLPS VRSVRRHLRF AATIMAPLIS QALQEDGKQR
     QKDALPTDQT EGRGTFISWL LRHLPEELRT PEQVGLDQML VSFAAIHTTT MALTKVIWEL
     AKRPEYIEPL RAEMHDVFGP EVGTRAICIN KDALSRLQKL DSFIREVQRW CPSAFACQKR
     RQHSRQS
//