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Database: UniProt
Entry: F9HEE6_9STRE
LinkDB: F9HEE6_9STRE
Original site: F9HEE6_9STRE 
ID   F9HEE6_9STRE            Unreviewed;       251 AA.
AC   F9HEE6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   SubName: Full=Chromosomal replication initiator protein DnaA {ECO:0000313|EMBL:EGP65726.1};
GN   Name=dnaA {ECO:0000313|EMBL:EGP65726.1};
GN   ORFNames=HMPREF9182_1273 {ECO:0000313|EMBL:EGP65726.1};
OS   Streptococcus sp. oral taxon 056 str. F0418.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=904294 {ECO:0000313|EMBL:EGP65726.1, ECO:0000313|Proteomes:UP000004514};
RN   [1] {ECO:0000313|Proteomes:UP000004514}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0418 {ECO:0000313|Proteomes:UP000004514};
RA   Durkin A.S., Kim M., Radune D., Hostetler J., Torralba M., Gillis M.,
RA   Methe B., Sutton G., Nelson K.E.;
RT   "Complete sequence of Bifidobacterium breves ACS-071-V-Sch8b.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGP65726.1}.
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DR   EMBL; AFQU01000001; EGP65726.1; -; Genomic_DNA.
DR   STRING; 904294.HMPREF9182_1273; -.
DR   EnsemblBacteria; EGP65726; EGP65726; HMPREF9182_1273.
DR   eggNOG; COG0593; LUCA.
DR   Proteomes; UP000004514; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004514};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004514}.
FT   DOMAIN      160    229       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   251 AA;  28786 MW;  B891FA4A5E7F7086 CRC64;
     MDSFKKIYRS LDLLLIDDIQ ALSKKVSTQE EFFNTFNALH GENKQIVLTS DRSPDYLENL
     EERLVTRFKW GLTSDITPPN FETRIAILRN KIEEFDLTFQ NETIEYLAGQ FDSNVRDLEG
     ALKDINLLAS MRNIKDITID LAAEAIRSRK QAGSQLLVIP IDRIQTEVGN FYGVSVKEMK
     GTRRVQNIVL ARQVAMYLAR ELTDNSLPKI GREFGGKDHT TVIHAHGKIK SMLEEDDNLR
     LEIETIKNKI K
//
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