ID F9LXJ0_STRMT Unreviewed; 141 AA.
AC F9LXJ0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000256|HAMAP-Rule:MF_01555};
DE EC=5.3.1.26 {ECO:0000256|HAMAP-Rule:MF_01555};
GN Name=lacA {ECO:0000256|HAMAP-Rule:MF_01555,
GN ECO:0000313|EMBL:EGU65728.1};
GN ORFNames=HMPREF9965_1357 {ECO:0000313|EMBL:EGU65728.1};
OS Streptococcus mitis bv. 2 str. SK95.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1000588 {ECO:0000313|EMBL:EGU65728.1, ECO:0000313|Proteomes:UP000003858};
RN [1] {ECO:0000313|EMBL:EGU65728.1, ECO:0000313|Proteomes:UP000003858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK95 {ECO:0000313|EMBL:EGU65728.1,
RC ECO:0000313|Proteomes:UP000003858};
RA Durkin A.S., Radune D., Hostetler J., Torralba M., Gillis M., Methe B.,
RA Sutton G., Nelson K.E.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_01555};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family.
CC {ECO:0000256|ARBA:ARBA00008754, ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGU65728.1}.
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DR EMBL; AFUB01000040; EGU65728.1; -; Genomic_DNA.
DR RefSeq; WP_000029278.1; NZ_AFUB01000040.1.
DR AlphaFoldDB; F9LXJ0; -.
DR PATRIC; fig|1000588.3.peg.1107; -.
DR eggNOG; COG0698; Bacteria.
DR OrthoDB; 1778624at2; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000003858; Unassembled WGS sequence.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR HAMAP; MF_01555; LacA; 1.
DR InterPro; IPR004783; LacA.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR NCBIfam; TIGR01118; lacA; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR30345:SF5; GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNIT LACA; 1.
DR PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01555, ECO:0000313|EMBL:EGU65728.1};
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736, ECO:0000256|HAMAP-
KW Rule:MF_01555}.
SQ SEQUENCE 141 AA; 15276 MW; 1CEB72397479E2BF CRC64;
MSIVIGADAA GLRLKEVVKD FLEKENFHVV DVTAEGQDFV DVTLAVAAEV NKEEQNLGIV
IDAYGAGPFM VATKIKGMVA AEVSDERSAY MTRGHNNSRM ITMGAQLVGN ELAKNIAKGF
VNGKYDGGRH QIRVDMLNKM C
//
