ID F9MKI2_STRMT Unreviewed; 453 AA.
AC F9MKI2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=23S rRNA (Uracil-5-)-methyltransferase RumA {ECO:0000313|EMBL:EGU70325.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:EGU70325.1};
GN Name=rumA_2 {ECO:0000313|EMBL:EGU70325.1};
GN ORFNames=HMPREF9959_0801 {ECO:0000313|EMBL:EGU70325.1};
OS Streptococcus mitis SK569.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1035187 {ECO:0000313|EMBL:EGU70325.1, ECO:0000313|Proteomes:UP000003550};
RN [1] {ECO:0000313|EMBL:EGU70325.1, ECO:0000313|Proteomes:UP000003550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK569 {ECO:0000313|EMBL:EGU70325.1,
RC ECO:0000313|Proteomes:UP000003550};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGU70325.1}.
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DR EMBL; AFUF01000038; EGU70325.1; -; Genomic_DNA.
DR RefSeq; WP_000914551.1; NZ_AFUF01000038.1.
DR AlphaFoldDB; F9MKI2; -.
DR PATRIC; fig|1035187.4.peg.1297; -.
DR eggNOG; COG2265; Bacteria.
DR Proteomes; UP000003550; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:GOC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR030391; MeTrfase_TrmA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR NCBIfam; TIGR00479; rumA; 1.
DR PANTHER; PTHR11061:SF48; 23S RRNA (URACIL(747)-C(5))-METHYLTRANSFERASE RLMC; 1.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR Pfam; PF01938; TRAM; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
DR PROSITE; PS01231; TRMA_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT DOMAIN 1..59
FT /note="TRAM"
FT /evidence="ECO:0000259|PROSITE:PS50926"
FT ACT_SITE 408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 408
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 283
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 312
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 333
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 381
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 453 AA; 51306 MW; 8927813D4A429BCC CRC64;
MLKKNDIVEV EIVDLTHEGA GVAKVDGLVF FVENALPSEK ILMRVLKVNK KIGFGKVEEY
LVQSPHRNQD LDLAYLRSGI ADLGHLAYPE QLKFKTKKVK DSLYKIAGIA DVEVAETLGM
ENPVKYRNKA QVPVRRVNGV LETGFFRKNS HDLMPLEDFF IQDSVIDEVV VALRDLLRRY
DLKPYDEKEQ AGLIRNLVVR RGHYSGQIMV ILVTTRPKVF RVEQLIDQLI KQFPEIVSVM
QNINDQNTNA IFGKEWRTLY GQDYITDQML ENDYQIAGPA FYQVNTQMAE KLYQTAIDFA
ELKADDVVID AYSGIGTIGL SVAKHVKEVY GVEVIPEAVE NSKKNAQLNN ISNAHYVCDT
AENAMKTWLK EGIQPTVILV DPPRKGLTES FIKASSQTGA DRIAYISCNV TTMARDIKLY
QELGYELKKV QPVDLFPQTH HVECVVLLQR KKG
//