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Database: UniProt
Entry: F9MQB5_9FIRM
LinkDB: F9MQB5_9FIRM
Original site: F9MQB5_9FIRM 
ID   F9MQB5_9FIRM            Unreviewed;       316 AA.
AC   F9MQB5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Putative L-lactate dehydrogenase {ECO:0000313|EMBL:EGS32626.1};
GN   ORFNames=HMPREF1040_1067 {ECO:0000313|EMBL:EGS32626.1};
OS   Megasphaera sp. UPII 135-E.
OC   Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC   Megasphaera.
OX   NCBI_TaxID=1000569 {ECO:0000313|EMBL:EGS32626.1, ECO:0000313|Proteomes:UP000004137};
RN   [1] {ECO:0000313|EMBL:EGS32626.1, ECO:0000313|Proteomes:UP000004137}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UPII 135-E {ECO:0000313|EMBL:EGS32626.1,
RC   ECO:0000313|Proteomes:UP000004137};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Nelson K.E.;
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
CC       {ECO:0000256|ARBA:ARBA00006054}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGS32626.1}.
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DR   EMBL; AFUG01000038; EGS32626.1; -; Genomic_DNA.
DR   RefSeq; WP_007393000.1; NZ_AFUG01000038.1.
DR   AlphaFoldDB; F9MQB5; -.
DR   eggNOG; COG0039; Bacteria.
DR   OrthoDB; 9802969at2; -.
DR   Proteomes; UP000004137; Unassembled WGS sequence.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF31; L-LACTATE DEHYDROGENASE; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|PIRSR:PIRSR000102-3};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004137}.
FT   DOMAIN          8..146
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          149..314
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   ACT_SITE        179
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
FT   BINDING         12..17
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         37
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         122..124
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
SQ   SEQUENCE   316 AA;  34438 MW;  6827AE5C8BD3EB58 CRC64;
     MGLKKRIVGV VGLGHVGAHV AFNLGMMGIA DAVYLCDKNE QKVLSEVQDL NDAAPFMPNH
     TVYTVVDYAG LKDCDIIVNA VGNIALLATH DRDKELENSV KEVADFIPKI MAAGFDGIFV
     NITNPCDVIT NLIREKSGLP TQRVVGTGTL LDSARLIAVI SKHTGLDARG FTAFMIGEHG
     NAQMAAWSCI SFYGKPLREL TNKKEFQFTK EESQAMAIKG AWVTYVGKQC TEYGVASAGA
     TLVRTILRDE KRIIPVSAYL NGEYGEKGIY CGIPAIISAK GVESIIEYEL TDEEKVEFKQ
     CCDAIRKNIE KSHALL
//
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