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Database: UniProt
Entry: F9PLC0_9ACTO
LinkDB: F9PLC0_9ACTO
Original site: F9PLC0_9ACTO 
ID   F9PLC0_9ACTO            Unreviewed;       556 AA.
AC   F9PLC0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   05-JUL-2017, entry version 40.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EGV12948.1};
GN   ORFNames=HMPREF9058_0299 {ECO:0000313|EMBL:EGV12948.1};
OS   Actinomyces sp. oral taxon 175 str. F0384.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=944560 {ECO:0000313|EMBL:EGV12948.1, ECO:0000313|Proteomes:UP000004281};
RN   [1] {ECO:0000313|EMBL:EGV12948.1, ECO:0000313|Proteomes:UP000004281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0384 {ECO:0000313|EMBL:EGV12948.1,
RC   ECO:0000313|Proteomes:UP000004281};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B.,
RA   Sutton G.G., Nelson K.E.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGV12948.1}.
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DR   EMBL; AFUR01000005; EGV12948.1; -; Genomic_DNA.
DR   RefSeq; WP_009406847.1; NZ_AFUR01000005.1.
DR   STRING; 944560.HMPREF9058_0299; -.
DR   EnsemblBacteria; EGV12948; EGV12948; HMPREF9058_0299.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004281; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004281};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004281}.
FT   DOMAIN      241    376       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      458    527       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     249    256       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   556 AA;  59767 MW;  57F9C73298E4868A CRC64;
     MPDAANTKWL SALEVLSSSG ELGQGKMSMI RMTHLIDVDG TLVLVVGSAF AKDIVEQARA
     PISAAITQVW GRPMPMEVTV DTSSEASRAP MTPMAPEPVN LATVAPAPAS SPSPSVPPQP
     SGPSTVPAAP APPTVPAYSE QLAEPSPYSA TAPSPMPYSQ ASAASAPSTM SGSLPTRSAH
     PGTYSPGGTG PQNPTGLLTP TAAHDVSQLN PRYTFDTYVT GSSNRFAHAT ALAVAEAPAR
     AYNPLFIYGG SGLGKTHLLH AIGHYAQTLN PGIRVKYVNS EVFVSDFIAC VRDGNQDDGR
     MEGFKRRYRE VDILLVDDIQ FLQGKESTLE EFFHTFNSLH SSGKQVVLTS DQPPKALGGL
     DERLRSRFEW GLLADVQPPD LETRIAILSR KGTAEGLDLP FDVLEYIASR ITTNIRELEG
     ALIRVTAFAS LNKQPVDQTL AEMVLKDIIS DPEGQEITTS LIMAQTADYF GITIDDLCSA
     NRSRTMVSAR HIAMYLCREL TDLSLPKIGR EFGGRDHTTV MSADKKIRTL MAERRSTFNQ
     VTELTSRIKQ AAQSPA
//
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