ID F9UT53_LACPL Unreviewed; 381 AA.
AC F9UT53;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cystathionine beta-lyase / cystathionine gamma-lyase {ECO:0000313|EMBL:CCC77784.1};
DE EC=4.4.1.1 {ECO:0000313|EMBL:CCC77784.1};
DE EC=4.4.1.8 {ECO:0000313|EMBL:CCC77784.1};
GN Name=cblB {ECO:0000313|EMBL:CCC77784.1};
GN OrderedLocusNames=lp_0255 {ECO:0000313|EMBL:CCC77784.1};
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668 {ECO:0000313|EMBL:CCC77784.1, ECO:0000313|Proteomes:UP000000432};
RN [1] {ECO:0000313|EMBL:CCC77784.1, ECO:0000313|Proteomes:UP000000432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1
RC {ECO:0000313|Proteomes:UP000000432};
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W., Stiekema W.,
RA Lankhorst R.M., Bron P.A., Hoffer S.M., Groot M.N., Kerkhoven R.,
RA de Vries M., Ursing B., de Vos W.M., Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WCFS1;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.F.T.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CCC77784.1, ECO:0000313|Proteomes:UP000000432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1
RC {ECO:0000313|Proteomes:UP000000432};
RX PubMed=22156394; DOI=10.1128/JB.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.F.T.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
RN [4] {ECO:0007829|PDB:6LDO, ECO:0007829|PDB:6LE4}
RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS).
RX PubMed=32913258; DOI=10.1038/s41598-020-71756-7;
RA Matoba Y., Noda M., Yoshida T., Oda K., Ezumi Y., Yasutake C.,
RA Izuhara-Kihara H., Danshiitsoodol N., Kumagai T., Sugiyama M.;
RT "Catalytic specificity of the Lactobacillus plantarum cystathionine gamma-
RT lyase presumed by the crystallographic analysis.";
RL Sci. Rep. 10:14886-14886(2020).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; AL935263; CCC77784.1; -; Genomic_DNA.
DR RefSeq; WP_011100941.1; NC_004567.2.
DR RefSeq; YP_004888298.1; NC_004567.2.
DR PDB; 6LDO; X-ray; 2.75 A; A/B/C/D/E/F=1-381.
DR PDB; 6LE4; X-ray; 3.10 A; A/B/C/D/E/F=1-381.
DR AlphaFoldDB; F9UT53; -.
DR SMR; F9UT53; -.
DR STRING; 220668.lp_0255; -.
DR EnsemblBacteria; CCC77784; CCC77784; lp_0255.
DR GeneID; 77216908; -.
DR KEGG; lpl:lp_0255; -.
DR PATRIC; fig|220668.9.peg.211; -.
DR eggNOG; COG0626; Bacteria.
DR HOGENOM; CLU_018986_2_0_9; -.
DR OrthoDB; 9780685at2; -.
DR PhylomeDB; F9UT53; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0004121; F:cystathionine beta-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0004123; F:cystathionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0080146; F:L-cysteine desulfhydrase activity; IEA:UniProtKB-EC.
DR GO; GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6LDO, ECO:0007829|PDB:6LE4};
KW Lyase {ECO:0000313|EMBL:CCC77784.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000432}.
FT MOD_RES 194
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 381 AA; 40865 MW; 1E676C0B3FF466F4 CRC64;
MKFETQLIHG GISEDATTGA TSVPIYMAST FRQTKIGQNQ YEYSRTGNPT RAAVEALIAT
LEHGSAGFAF ASGSAAINTV FSLFSAGDHI IVGNDVYGGT FRLIDAVLKH FGMTFTAVDT
RDLAAVEAAI TPTTKAIYLE TPTNPLLHIT DIAAIAKLAQ AHDLLSIIDN TFASPYVQKP
LDLGVDIVLH SASKYLGGHS DVIGGLVVTK TPALGEKIGY LQNAIGSILA PQESWLLQRG
MKTLALRMQA HLNNAAKIFT YLKSHPAVTK IYYPGDPDNP DFSIAKQQMN GFGAMISFEL
QPGMNPQTFV EHLQVITLAE SLGALESLIE IPALMTHGAI PRTIRLQNGI KDELIRLSVG
VEASDDLLAD LERGFASIQA D
//
