ID F9VNG2_SULTO Unreviewed; 318 AA.
AC F9VNG2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Malonate-semialdehyde reductase {ECO:0000313|EMBL:BAK54608.1};
DE EC=1.1.1.298 {ECO:0000313|EMBL:BAK54608.1};
GN Name=ST1507 {ECO:0000313|EMBL:BAK54608.1};
GN OrderedLocusNames=STK_15070 {ECO:0000313|EMBL:BAK54608.1};
OS Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
OS (Sulfolobus tokodaii).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfurisphaera.
OX NCBI_TaxID=273063 {ECO:0000313|EMBL:BAK54608.1, ECO:0000313|Proteomes:UP000001015};
RN [1] {ECO:0000313|Proteomes:UP000001015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16993 / JCM 10545 / NBRC 100140 / 7
RC {ECO:0000313|Proteomes:UP000001015};
RX PubMed=11572479; DOI=10.1093/dnares/8.4.123;
RA Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M.,
RA Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y.,
RA Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T.,
RA Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K.,
RA Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H.;
RT "Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon,
RT Sulfolobus tokodaii strain7.";
RL DNA Res. 8:123-140(2001).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
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DR EMBL; BA000023; BAK54608.1; -; Genomic_DNA.
DR RefSeq; WP_010979557.1; NC_003106.2.
DR AlphaFoldDB; F9VNG2; -.
DR STRING; 273063.STK_15070; -.
DR GeneID; 1459543; -.
DR KEGG; sto:STK_15070; -.
DR PATRIC; fig|273063.9.peg.1715; -.
DR eggNOG; arCOG00251; Archaea.
DR OrthoDB; 51300at2157; -.
DR Proteomes; UP000001015; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035527; F:3-hydroxypropionate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:BAK54608.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001015}.
FT DOMAIN 6..185
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..273
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 142
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 318 AA; 36258 MW; EAA1737A7369FF58 CRC64;
MRQIKTVSVI GAGVIGAGWS TLLALKGYEN WFYTEKKETL DKGLAKIKGY LNVLYEYKLI
DKEPDYYMQR IHPTTKLDEA ISNTDFVLEA IVEEYGAKKA LFKQLDEKLD KDVILASSTS
GLLMTEIQKA MTKYPERGII AHPWNPPHLL PLVEIVPGEK TSQDTIYATK DFMENKLERV
VVVLKKEISG FIGNRLAFAL FREAVYLVDE GIATVEDIDK VMTAAIGLRW AFMGPFLTYH
LGGGEGGLEY FFSRGFGYGA NEWMHTLAKY DKFPYTGVVK SVQQMKEYEF VKSKTFQELS
RWRDEKLISL IKLLRGKI
//
