ID F9W5R0_TRYCI Unreviewed; 1241 AA.
AC F9W5R0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN ORFNames=TCIL3000_0_33850 {ECO:0000313|EMBL:CCD12513.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCD12513.1, ECO:0000313|Proteomes:UP000000702};
RN [1] {ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|Proteomes:UP000000702};
RA Jackson A.P., Berry A., Allison H.C., Burton P., Anderson J., Aslett M.,
RA Brown R., Corton N., Harris D., Hauser H., Gamble J., Gilderthorp R.,
RA McQuillan J., Quail M.A., Sanders M., Van Tonder A., Ginger M.L.,
RA Donelson J.E., Field M.C., Barry J.D., Berriman M., Hertz-Fowler C.;
RT "Divergent evolution of antigenic variation in African trypanosomes.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCD12513.1, ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCD12513.1,
RC ECO:0000313|Proteomes:UP000000702};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- FUNCTION: Could act as a receptor for an unknown ligand.
CC {ECO:0000256|ARBA:ARBA00002708}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCD12513.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAEQ01000752; CCD12513.1; -; Genomic_DNA.
DR AlphaFoldDB; F9W5R0; -.
DR VEuPathDB; TriTrypDB:TcIL3000_0_33850; -.
DR OMA; LEYMEVF; -.
DR OrthoDB; 121229at2759; -.
DR Proteomes; UP000000702; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07556; Nucleotidyl_cyc_III; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR028081; Leu-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13458; Peripla_BP_6; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000702};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 857..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 900..1054
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1241 AA; 136027 MW; CDE0BCEFE3A215E9 CRC64;
MCALASHGNG RHSPLSYWDV VLEWAMRGAL HRSSRRRVSH VSATVLSLLL LLLSLLRVCA
EDAVPTVHVV SLMYDTSDDV DVINAINAGF DASVSARGWK TSSVARISVT RPNSYNTSVG
DILQEGIQKS DGKLLIALGP LGTENVAAAL PALKKNNVVG FAAMAHSNEA RGWNPNLYFL
GVGPVAELLA LIRYAVARMG VVRLGMAYMR DGNGMESYES AVNILSMMGR ELCGTFVVAS
GKGDHVSEDA EWEKFIKTRP QAVLLFANVM DDTTVWFINK MVQDDRAAGV YVLAPTRLQG
FLYRAWNSAL NSTDAQLTPG QLITAGAVPL ANDNTSAMIQ RFQKEMDSYL GTNEDWSGFA
KPKHYLEDEG IGEMMVVGWL AGEILTQALN SNMQLTNRTA FMESLYMQRR YVIDDFVVGD
FGGNCTDGAA QRGATCHCNQ GGSMVYLKNV VEGFRLEPLP SGYLSRDLKD CAGESVEVGA
PLLALFVVVT DDAIASRATV RWFTGAVALD DATGSADDRI FFHPLEVTKA NATAALENLR
DTKVVSAVFG VVPGEMLNMR NMTFINPIAL TPRVNTFRRN VLHILPLIAQ QLYVSAVYMS
NTSLGKVKAF IRGDHAAAME DVLEKSLVTF GLTLESATTL SYDVPMAPQL PKSGDVFTIG
LAASDIPEIA DHLQRHRRLR VFVPFNDIAL LYDEFLSAFN ATPQSIESSS RLLFSTSLPH
WADRSSQSLT VINFHKLVVN ESCWTPLTYL GFATARLLQT ILPRMQKVSP ELLSDFFFEE
SNIKVDDTWY GPFIDTECIS GGTASANNCA SNFGASNLSV WSMARVLNAS VPVLQQGITP
SLEYAIKAEG RLTRSQVIGV IVGSVLAVLL LVALCVLLYL SLGNTRDNDR APMESSDPVT
LIFTDIESST AQWAAYPELM PDAVAAHHRM IRQVAGRYNC YEVKTVGDSF MIASKSPFAA
VQLARDIQCC FLHHDWGTNL FDEFYRMFEE ERASSGEGYR PVTACLDPDV YRELWNGLRV
RIGIHTGLCD IRHDEVTKGY DYYGHTPNMA ARTESVANGG QVLLTEATYL ALSAAEREQT
DVTSLGLVPL RGMAAPVGMY QLDAVPGRSF AALRLDREYF FDDDEGTTTS TSDHSSARTE
LSESAQIIVT ALQSLLSTFK APQREKLLMP YCERWRVPLP RKGAAAWDDG YCEEVVRRIA
MKVGRVTDHG AHSASDASSS THPSSSVIVI SYLGPNYHED Y
//
