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Database: UniProt
Entry: F9WCE4_TRYCI
LinkDB: F9WCE4_TRYCI
Original site: F9WCE4_TRYCI 
ID   F9WCE4_TRYCI            Unreviewed;       657 AA.
AC   F9WCE4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=GMP synthase (glutamine-hydrolyzing) {ECO:0000256|ARBA:ARBA00012746};
DE            EC=6.3.5.2 {ECO:0000256|ARBA:ARBA00012746};
DE   AltName: Full=Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00031356};
GN   ORFNames=TCIL3000_0_55050 {ECO:0000313|EMBL:CCD14937.1};
OS   Trypanosoma congolense (strain IL3000).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX   NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCD14937.1, ECO:0000313|Proteomes:UP000000702};
RN   [1] {ECO:0000313|Proteomes:UP000000702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL3000 {ECO:0000313|Proteomes:UP000000702};
RA   Jackson A.P., Berry A., Allison H.C., Burton P., Anderson J., Aslett M.,
RA   Brown R., Corton N., Harris D., Hauser H., Gamble J., Gilderthorp R.,
RA   McQuillan J., Quail M.A., Sanders M., Van Tonder A., Ginger M.L.,
RA   Donelson J.E., Field M.C., Barry J.D., Berriman M., Hertz-Fowler C.;
RT   "Divergent evolution of antigenic variation in African trypanosomes.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCD14937.1, ECO:0000313|Proteomes:UP000000702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL3000 {ECO:0000313|EMBL:CCD14937.1,
RC   ECO:0000313|Proteomes:UP000000702};
RX   PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA   Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA   Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA   Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA   Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA   Hertz-Fowler C., Berriman M.;
RT   "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT   African trypanosome species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC   -!- PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln
CC       route): step 1/1. {ECO:0000256|ARBA:ARBA00005153}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCD14937.1}.
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DR   EMBL; CAEQ01001707; CCD14937.1; -; Genomic_DNA.
DR   AlphaFoldDB; F9WCE4; -.
DR   MEROPS; C26.A21; -.
DR   VEuPathDB; TriTrypDB:TcIL3000_0_55050; -.
DR   OMA; DQLTCMF; -.
DR   OrthoDB; 6206at2759; -.
DR   UniPathway; UPA00189; UER00296.
DR   Proteomes; UP000000702; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003921; F:GMP synthase activity; IEA:InterPro.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01742; GATase1_GMP_Synthase; 1.
DR   Gene3D; 3.30.300.10; -; 2.
DR   Gene3D; 3.40.50.880; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR017926; GATASE.
DR   InterPro; IPR001674; GMP_synth_C.
DR   InterPro; IPR004739; GMP_synth_GATase.
DR   InterPro; IPR025777; GMPS_ATP_PPase_dom.
DR   InterPro; IPR022310; NAD/GMP_synthase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00888; guaA_Nterm; 1.
DR   PANTHER; PTHR11922:SF2; GMP SYNTHASE [GLUTAMINE-HYDROLYZING]; 1.
DR   PANTHER; PTHR11922; GMP SYNTHASE-RELATED; 1.
DR   Pfam; PF00117; GATase; 1.
DR   Pfam; PF00958; GMP_synt_C; 1.
DR   Pfam; PF02540; NAD_synthase; 1.
DR   PRINTS; PR00097; ANTSNTHASEII.
DR   PRINTS; PR00096; GATASE.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR   SUPFAM; SSF54810; GMP synthetase C-terminal dimerisation domain; 2.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
DR   PROSITE; PS51553; GMPS_ATP_PPASE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00886};
KW   Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW   ECO:0000256|PROSITE-ProRule:PRU00605};
KW   GMP biosynthesis {ECO:0000256|ARBA:ARBA00022749, ECO:0000256|PROSITE-
KW   ProRule:PRU00886}; Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00886};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755, ECO:0000256|PROSITE-
KW   ProRule:PRU00886}; Reference proteome {ECO:0000313|Proteomes:UP000000702}.
FT   DOMAIN          201..417
FT                   /note="GMPS ATP-PPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51553"
FT   ACT_SITE        88
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        175
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        177
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT   BINDING         229..235
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00886"
SQ   SEQUENCE   657 AA;  72068 MW;  5CABDD9043A18E76 CRC64;
     MSVQPQSEEY IAILDAGSQY GKVIDRRVRE LRVESRVMPL NTPTEVLRGD PSIKGVIISG
     GPSSIYDSNA PSYNKDLFEL GKPLLGICYG MQLLTEAFGG EVGRADVRED GQDEITVDTT
     SPIFAGLSQR ETVLLTHGDS IISPGTELKV MARSSANIIA AVQHQTRPLF GVQFHPEVEL
     TKNGVQILRN FLELCGCAFA FTMEDREEKA LRLIRERTAK GQKVLCLASG GVDSTVCAVL
     LLKAIGPERV VCVHIDHGFM RLNESELVVA ALKAAGVNVT LVSAAEQFAQ ATTEFPARRG
     KGPYQTGKLC ETKDPEEKRV IIGNTFMAVC NKVVKDLGLD MDNLLLAQGT LRPDLIESGS
     LYASKLADAI KTHHNDTDVV RQLREKGQII EPLCDYHKDE VRELGVRLGI PSHLVQRQPF
     PGPGLAIRLL CSDGTPFRDK QFAPTEEILR SVCSGDNQFE LLKPLRPTIK NLQPAGCVLP
     VRTVGVQGDG RTYAYAAALS LGHFPLGEEW KVLNQLALII PKISTDINRI VFMFGSKRVE
     SPKTVTKSFL VPETLNKLRL ADNLVNEVLL KYNLVRRLSQ VAVILLPVGL EEKGDFSIVI
     RTFITNDFMT GVPAVPGTPD MPLEALKEMV AALETLDFAS RVMYDMTGKP PGTTEWE
//
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