ID F9WHL9_TRYCI Unreviewed; 1655 AA.
AC F9WHL9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=WGS project CAEQ00000000 data, annotated contig 667 {ECO:0000313|EMBL:CCD16812.1};
DE Flags: Fragment;
GN ORFNames=TCIL3000_0_17110 {ECO:0000313|EMBL:CCD16812.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCD16812.1, ECO:0000313|Proteomes:UP000000702};
RN [1] {ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|Proteomes:UP000000702};
RA Jackson A.P., Berry A., Allison H.C., Burton P., Anderson J., Aslett M.,
RA Brown R., Corton N., Harris D., Hauser H., Gamble J., Gilderthorp R.,
RA McQuillan J., Quail M.A., Sanders M., Van Tonder A., Ginger M.L.,
RA Donelson J.E., Field M.C., Barry J.D., Berriman M., Hertz-Fowler C.;
RT "Divergent evolution of antigenic variation in African trypanosomes.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCD16812.1, ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCD16812.1,
RC ECO:0000313|Proteomes:UP000000702};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCD16812.1}.
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DR EMBL; CAEQ01002456; CCD16812.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:TcIL3000_0_17110; -.
DR OMA; LEDKHVN; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000000702; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000702}.
FT DOMAIN 128..529
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 658..984
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1163..1300
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 1519..1596
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT COILED 37..72
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1655
FT /evidence="ECO:0000313|EMBL:CCD16812.1"
SQ SEQUENCE 1655 AA; 188515 MW; C0FC32FB50EA8A74 CRC64;
MRQYYNVLDG FQYELSDEES RQKWEAIGWP RQLTMRIQET NKQLEKVEEE LHARLQKEGE
EFSKKVDALQ RVVATFSKYT DAAEAEKVAA EVKVNSIEIR KCIEQARSIN SDQRLFGDKL
TDYRSVFELE KEFKPYSDLW LTAYQWQDCY RRWHTDPFDS LDHEEIETVV ANSFKTLTQL
SKAFKDKNAT LKIVSELREK VEAFKKWVPI VTSLRQPGMK ERHWKGLSEK LNMSLVPGEN
VLLIEDVEPL LNFKDIIVPH CEVAAKEAQI EKSLKDMRAK WESRVFVIEA YKETGTYIIK
DASEIVELLD EHLNLTQQLQ FSPFKAFYAE AITDWERSLN LISDIIEQWL ECQRAWRYLE
PIFNAKDIAL QLPRLTKLFD RVDKTWRRVM GTAHNQPNVL DFCIGTSKLL ESLRESNRIL
EEVQRGLNDY LGEKRQTFPR FYFLSDEELL EILSQSKEVR RIDAHISKLF EFIQKLSWTE
GNEINGFYSG EGEHVPSVNP VSPEGNVEIW LGSVETMMKE AVADQLRQSF CAYRKTPRSS
WVLQWPAQCV IAVSQIFWTN GCEEDLSSQC NVEGFFKVLE RQLFELVDVV QSPLNMRERI
NMGALITVEV HAKDTVEAMV RCKVESAQSF EWIKQLRFYF DAEDRMCHIK QVDAHFVYGG
EYLGNTGRLV VTPLTDRIYL TLTGALALCL GGAPAGPAGT GKTETTKDLA KALAKQCVVF
NCQEGMTCLS MAKFFKGLAW AGAWACFDEF NRIDVEVLSV VAQQVTDLQQ ACVTKQYRIV
FEGNEVVVDP THAVFITMNP GYAGRTELPD NLKVLFRPVA CMVPDYAMIG EIRLFSYGYK
KARSLAQKMV MTFKLSSEQL SSQDHYDFGM RAVNTVISAA GLNKRENPNE DEDLLLLRAL
RDSNAPKFLK DDIVLFEGII SDLFPGTKLS ATDYGAVVDT LQQAITSNHL QPTPAFVEKC
LQLYDITTLR HGLMLVGPAG SGKTMAYTSL QRALSECSVM QSKGHDIGPR DYMKVYTHIC
NPKAVTMDQL YGAYDENGEW KDGVLCVLFR RAAKYGDEGN QIGKHWVMFD GPVDALWIES
MNTVLDENKK LCLVSGEIIQ MSRDMTMMFE VEDLAVASPA TVSRCGMIYM EPTACVPTPA
LTKSWKERLP KYLSQQADYL VGLVELYADE LIEFLRANLR EYVPSTNVSL VHSFFRMMDG
YVQSLGGPTG QRTPVAITPE RLELIAKCIT PMFFMAITWS IGATCDEEGR EKFSEKLREI
ATQNGHVSYL PEDGVVYDYC YMYSMLPDDD EEPRWVHWDE LCETCEVGRT TKFEDVFVPT
IDNTRQKYVL KHLLEQKTNV VVVGPTGTGK SVAAGGLVLS GVSDNLLGLV FTFTPQTKAG
ALQDSLMSKF DKRRSHVYGA PVGKHFLVFI DDANLPQKER YGAQPPLELL RQLLGHGGLY
SFTGGIKWNS VIDTSFVMAM GPPGGSRTQV SNRLMRYFNY VSFPEMSEAS KRTILNTIIK
GGLRQRGVEE DITNLTPSLV DATLKIFKRC RKAFVPTPSH VHYSFNMRDV MRVFPMIYIN
DSSSLADRDV LLRQWVHEMQ RVFCDRLICT QDREEFLSFI DEEVVQMGYE GGYKALVPEG
RLIFGDFMST GDRAYHQITD MTALAAFFNE QLAAY
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