ID F9WPC0_TRYVY Unreviewed; 357 AA.
AC F9WPC0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Metacaspase MCA3, putative {ECO:0000313|EMBL:CCD19397.1};
GN ORFNames=TvY486_0020990 {ECO:0000313|EMBL:CCD19397.1};
OS Trypanosoma vivax (strain Y486).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX NCBI_TaxID=1055687 {ECO:0000313|EMBL:CCD19397.1, ECO:0000313|Proteomes:UP000009027};
RN [1] {ECO:0000313|EMBL:CCD19397.1, ECO:0000313|Proteomes:UP000009027}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y486 {ECO:0000313|EMBL:CCD19397.1,
RC ECO:0000313|Proteomes:UP000009027};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- SIMILARITY: Belongs to the peptidase C14B family.
CC {ECO:0000256|ARBA:ARBA00009005}.
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DR EMBL; CAEX01003341; CCD19397.1; -; Genomic_DNA.
DR AlphaFoldDB; F9WPC0; -.
DR VEuPathDB; TriTrypDB:TvY486_0020990; -.
DR OMA; ERCSWCG; -.
DR OrthoDB; 1077459at2759; -.
DR Proteomes; UP000009027; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.12660; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR PANTHER; PTHR48104; METACASPASE-4; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009027}.
FT DOMAIN 84..334
FT /note="Peptidase C14 caspase"
FT /evidence="ECO:0000259|Pfam:PF00656"
SQ SEQUENCE 357 AA; 39387 MW; 9965C0743BC0FCA3 CRC64;
MGFDPQCLIS ICNVLMTARN QKGAVNFIDV ATSLLKVAGP YIVQYLGEVP RPQEVNVDDA
LSDAESAQGF KPWESSEPVS GEVRALFIGI NYYGTSAKLS GCCNDVRQMI GTLQRRKFPI
TSMNILVDED DFPGRTDQPT RANILRYMAW LVKDAKPGDV LFLHFSGHGT QTKAANDSEE
EFDQCIAPVD FKQNGCILDD DIYNLLLSRL PEGVRFTAVF DCCHSGSMMD LPFTYVCRSS
EHRSSAGHMK RIRQGNDVKA DVLMISGCED KQTSADVQNT ATFGTGSTGA GGAATQCLTI
MMLKETSLSY RDVLLATRDK LKQKRFTQVP QMSASKPIDL NQKFSLKEKF LTDHSVA
//
