ID   F9WSH0_TRYVY            Unreviewed;       970 AA.
AC   F9WSH0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Reverse transcriptase (RNA-dependent DNA polymerase) {ECO:0000313|EMBL:CCD20509.1};
GN   ORFNames=TvY486_0033470 {ECO:0000313|EMBL:CCD20509.1};
OS   Trypanosoma vivax (strain Y486).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX   NCBI_TaxID=1055687 {ECO:0000313|EMBL:CCD20509.1, ECO:0000313|Proteomes:UP000009027};
RN   [1] {ECO:0000313|EMBL:CCD20509.1, ECO:0000313|Proteomes:UP000009027}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Y486 {ECO:0000313|EMBL:CCD20509.1,
RC   ECO:0000313|Proteomes:UP000009027};
RX   PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA   Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA   Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA   Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA   Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA   Hertz-Fowler C., Berriman M.;
RT   "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT   African trypanosome species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
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DR   EMBL; CAEX01005748; CCD20509.1; -; Genomic_DNA.
DR   AlphaFoldDB; F9WSH0; -.
DR   VEuPathDB; TriTrypDB:TvY486_0033470; -.
DR   OrthoDB; 119427at2759; -.
DR   Proteomes; UP000009027; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR046836; RHS_C.
DR   InterPro; IPR046835; RHS_N.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR006518; Trypano_RHS.
DR   NCBIfam; TIGR01631; Trypano_RHS; 1.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF20445; RHS_N; 1.
DR   Pfam; PF07999; RHSP; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:CCD20509.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009027};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:CCD20509.1};
KW   Transferase {ECO:0000313|EMBL:CCD20509.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        23..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          695..933
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          94..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   970 AA;  106591 MW;  C44118C163F77CD2 CRC64;
     MDSPAGVHRT YRLEAAVQER GCFAVHLTLL VVLVKFFFFF FFGLHSKRTR SQKRVREQRR
     LAFPTHETPA MGGSSSALRH GRYKVPWYGE VRSVEQQESP QSAKTRTTSR ENSSRVSNRT
     CAPGGRHATL AGAVSEGLDG SVERSGTCPG SPRPRRSASC HAGHATRRSR SVASCSTRSV
     GGEGRGCVTG ARTPIRLGRR QPSAHLPLSG RRAHSLDREN AIPPPQHRPV SGGVRCAQRA
     PSAPRPRSTR SESRMARHTP VVHVPNSVLL EALKEMNLSL NRLDAKIRSG LDAVNKEISD
     IRGGTAGTRG ASPQPAARVS EDITYVMEHL CSIAWCYVES GHADEPLGMA IATQNGGRHR
     GARGAVRNGA AASVGDVLEL MVCNDRLALV ILASAVGWPC EGFSQGGCTG VDIGNHPWSH
     DVFVRRETLR VWSIVSQDLR HTASGLSAHM PHAFVLYGSH GIGKSFGVGS FLLFMLLQHS
     AEEVPVVAYL MGERLYLFQK AWRGRSARAT FTQGSEASLQ MVNQAMKENK RGYFIYDAPV
     QEQLGVAEWA MASGWGGILL DAQNEKARAN WGRRGGCRSI CVNPMTEVEL KAVLVWTERD
     VLHRGALALA GKKWAEIRER VRSVGPLLKY VLDGKRYMSR LQGVMEQLSL ASEGDVGRCV
     DALIFNEGSL GRKRHRKLVK LVRTGAHSGG DQFRTFAVSE MVFDELIKTS IFAHARRRDV
     SSFVKLLAQR VGVRLARSTL DALMQVTNSS RRRKDSGKTA AVFIDCARAF DSVDRGYIVK
     ELLSFGVGRR LVSWNAGFLQ ERTAQGRVNN ALPEDIDLTC GVPQRSVLGP LLFIVTADSL
     SRRLNRVPVL QHGFFADDLT IVRTSADLNE IQQTIQQGLD CITNWSAEYC MEVSGEKTEY
     TLFGARETNL LGLKVGETAL KEERTPKLLG LTMQPHKGLS KHVLCMKAVA NTRLMHLRPV
     ALPEWGPEGY
//