ID F9XFY3_ZYMTI Unreviewed; 1129 AA.
AC F9XFY3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=RhoGAP-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MYCGRDRAFT_86888 {ECO:0000313|EMBL:EGP85701.1};
OS Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch
OS fungus) (Septoria tritici).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX NCBI_TaxID=336722 {ECO:0000313|EMBL:EGP85701.1, ECO:0000313|Proteomes:UP000008062};
RN [1] {ECO:0000313|EMBL:EGP85701.1, ECO:0000313|Proteomes:UP000008062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115943 / IPO323 {ECO:0000313|Proteomes:UP000008062};
RX PubMed=21695235; DOI=10.1371/journal.pgen.1002070;
RA Goodwin S.B., Ben M'barek S., Dhillon B., Wittenberg A.H.J., Crane C.F.,
RA Hane J.K., Foster A.J., Van der Lee T.A.J., Grimwood J., Aerts A.,
RA Antoniw J., Bailey A., Bluhm B., Bowler J., Bristow J., van der Burgt A.,
RA Canto-Canche B., Churchill A.C.L., Conde-Ferraez L., Cools H.J.,
RA Coutinho P.M., Csukai M., Dehal P., De Wit P., Donzelli B.,
RA van de Geest H.C., van Ham R.C.H.J., Hammond-Kosack K.E., Henrissat B.,
RA Kilian A., Kobayashi A.K., Koopmann E., Kourmpetis Y., Kuzniar A.,
RA Lindquist E., Lombard V., Maliepaard C., Martins N., Mehrabi R.,
RA Nap J.P.H., Ponomarenko A., Rudd J.J., Salamov A., Schmutz J.,
RA Schouten H.J., Shapiro H., Stergiopoulos I., Torriani S.F.F., Tu H.,
RA de Vries R.P., Waalwijk C., Ware S.B., Wiebenga A., Zwiers L.-H.,
RA Oliver R.P., Grigoriev I.V., Kema G.H.J.;
RT "Finished genome of the fungal wheat pathogen Mycosphaerella graminicola
RT reveals dispensome structure, chromosome plasticity, and stealth
RT pathogenesis.";
RL PLoS Genet. 7:E1002070-E1002070(2011).
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DR EMBL; CM001202; EGP85701.1; -; Genomic_DNA.
DR RefSeq; XP_003850725.1; XM_003850677.1.
DR AlphaFoldDB; F9XFY3; -.
DR STRING; 336722.F9XFY3; -.
DR EnsemblFungi; Mycgr3T86888; Mycgr3P86888; Mycgr3G86888.
DR GeneID; 13397463; -.
DR KEGG; ztr:MYCGRDRAFT_86888; -.
DR eggNOG; KOG4269; Eukaryota.
DR HOGENOM; CLU_002671_0_0_1; -.
DR InParanoid; F9XFY3; -.
DR OMA; HSPANIE; -.
DR OrthoDB; 25690at2759; -.
DR Proteomes; UP000008062; Chromosome 7.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13277; PH_Bem3; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF137; GTPASE ACTIVATOR (BEM3), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06400)-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008062}.
FT DOMAIN 561..672
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 839..1055
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..110
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..345
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1129 AA; 122076 MW; EB5FA12A58A1F972 CRC64;
MTPQRTTSID STVSSISSLT SATPRAHGSA DRVPQDQVED AATLIAAAGS AEAALQKVLN
EKQQAASHNA QLWRLVEKQR TMILGLNKDL EKSLKEKERY RRKLKDHLAQ SISAPALISA
QASGSGSREA SVSPAGDAAS GYTTKTLRKG SDGTESLLSK SSRSDTPLDA GIMSTSVLLP
ASPQSSSSTS AEFRMADRDG RNQFDTAPRI GKNVSIPETI TAAQSAAISP SSQSFSSPKT
RKAPPAPLKL NPPKPEPQVR NNIIDASDSE YEEDPESARG EYLDRGPRQR VFEATATPAD
IVRNRAVSDA TALLRKKEPP AAMLSPGLPM SPRPSDRPPN SPMPRSNVSI PMSPKHLHPY
PQAMSSVAER LMPPGDGSPG SERPSTSSER TMFTPGEVYQ GFMSDQYPGL LLPPNALASI
YVKTASSRMR PSRASFIAPR PGDENPVFTL AVHERSEDKQ LWRVEKTFAS LALLDQQVKA
VIKLRDRLPD KALFAGHAPA KIDARRMALN YYFDRMLDAM VEEKAALIFC KFLSTDAVGG
DGDYFGGLAD ARPDSPVAQL RPNRAGYLTK RGKNFGGWKA RYFVLDGPSL KYFEGPGGAH
LGSIRLQNAQ IGKQSSTVAQ SSHEDEDNQF RHAFLILEPK KKDSTSLVRH VLCAESDEER
DAWVEALLQY VDYRDDEDTN LAQQAQQSKT EVMPRSPRLR KSMNDLRSGS GSSQGTGNRS
ADLVRTVNYS EVAAGDAPIM GMKSPLGSAT PSPPYDKTSS AEHTGHNISG PTNLQVIQNT
GDWGMKAPPT PGGKDKKRSV FALPFTRGRS SSDLMPGEGV KSPGLPPDKS SLSRAVFGLP
LADAAAITPA PDGASELPAV VYRCIQYLTL KNAIAEEGIF RLSGSNTVIR ALKDRFNTEG
DVNLVMDVNS YDVHAVASLL KLYLRELPAS ILTRDLHLDF LHCLELIGDE KIFALNSLVN
RLPGPNRALL EALSAFMLTI VNNVGVNKMN VRNLGVVFSP TLNVPGPLIS LFVEEQHRIF
GDELPLSESS TPTSSATRHS PASSTDLRSP RKQMFTDLPT PAYNQTAFQH GPGGAPLDDT
GMVPLNPAYA YHQMAPQDAK AKRRESSLLV AGAYSSGPQK KSIHDMHAL
//
