ID FBP2_STRPU Reviewed; 325 AA.
AC P15216;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Fibropellin-2;
DE AltName: Full=Epidermal growth factor-related protein 2;
DE AltName: Full=Fibropellin II;
DE Flags: Precursor;
GN Name=EGF2;
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2814501; DOI=10.1126/science.2814501;
RA Yang O., Angerer L.M., Angerer R.C.;
RT "Unusual pattern of accumulation of mRNA encoding EGF-related protein in
RT sea urchin embryos.";
RL Science 246:806-808(1989).
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DR EMBL; M29004; AAA30044.1; -; mRNA.
DR PIR; A40084; A40084.
DR RefSeq; NP_999696.1; NM_214531.1.
DR AlphaFoldDB; P15216; -.
DR EnsemblMetazoa; NM_214531; NP_999696; GeneID_373304.
DR GeneID; 373304; -.
DR KEGG; spu:373304; -.
DR CTD; 373304; -.
DR HOGENOM; CLU_1973302_0_0_1; -.
DR InParanoid; P15216; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF00008; EGF; 2.
DR SMART; SM00181; EGF; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; EGF-like domain; Reference proteome; Repeat; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..325
FT /note="Fibropellin-2"
FT /id="PRO_0000007587"
FT DOMAIN 48..91
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 107..152
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 178..224
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 252..293
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 52..65
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 59..75
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 77..90
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 111..124
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 118..137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 139..151
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 182..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 189..209
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 211..223
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 256..269
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 263..278
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 280..292
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 325 AA; 36898 MW; F09BA8805654C7AC CRC64;
MQFNLVFVVA VIGVGMVAAD ENLMSKLQMA LKSMLNENEE LQMQSRDTKG QCESDTNKCN
NHGTCIEGRW GTYYCKCEMP FRVGIPDSSC YPPPEGKKDL EIEARDSENR CLSDTSNCDG
HGICQLSTFG RNERYICFCA LGFRNNNYGG CSPYTPREIE FLSYVARDLE LEMLTRDSLG
RCKSDTHNCD EAGQCVTKTY GRYAGEYICV CNHGYRNNAY GGCSPMTTRE IEYLDMLARE
EQMQMLVRKY YSLSECSQGT NDCNENGECV EEDGKYWCEC GEGYEENEDG GCSPIVTRAT
EVDDDDFAER KKEIMRQLAE FLQEE
//
