ID FIS_BUCAP Reviewed; 99 AA.
AC Q8K9F0;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=DNA-binding protein Fis {ECO:0000255|HAMAP-Rule:MF_00166};
GN Name=fis {ECO:0000255|HAMAP-Rule:MF_00166}; OrderedLocusNames=BUsg_387;
OS Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=198804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sg;
RX PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
CC -!- FUNCTION: Activates ribosomal RNA transcription. Plays a direct role in
CC upstream activation of rRNA promoters. {ECO:0000255|HAMAP-
CC Rule:MF_00166}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00166}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Fis family.
CC {ECO:0000255|HAMAP-Rule:MF_00166}.
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DR EMBL; AE013218; AAM67939.1; -; Genomic_DNA.
DR RefSeq; WP_011053906.1; NC_004061.1.
DR AlphaFoldDB; Q8K9F0; -.
DR SMR; Q8K9F0; -.
DR STRING; 198804.BUsg_387; -.
DR GeneID; 75258734; -.
DR KEGG; bas:BUsg_387; -.
DR eggNOG; COG2901; Bacteria.
DR HOGENOM; CLU_158040_3_0_6; -.
DR Proteomes; UP000000416; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR HAMAP; MF_00166; DNA_binding_Fis; 1.
DR InterPro; IPR005412; Fis_DNA-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR PANTHER; PTHR47918; DNA-BINDING PROTEIN FIS; 1.
DR PANTHER; PTHR47918:SF1; DNA-BINDING PROTEIN FIS; 1.
DR Pfam; PF02954; HTH_8; 1.
DR PIRSF; PIRSF002097; DNA-binding_Fis; 1.
DR PRINTS; PR01591; DNABINDNGFIS.
DR PRINTS; PR01590; HTHFIS.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..99
FT /note="DNA-binding protein Fis"
FT /id="PRO_0000203877"
FT DNA_BIND 75..94
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00166"
SQ SEQUENCE 99 AA; 11497 MW; FA5B8CD8B55B4F48 CRC64;
MSEESMDTGF LVINTKDKQD KTVKKPLRIL IKKSLENYFL HLDKSQCVSN LYQLVLSELE
QPLLDIIMQH TRGNQTRAAS IMGINRSTLR KKLKRYGMN
//
