ID FIS_YERPG Reviewed; 98 AA.
AC A9R1Z3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=DNA-binding protein Fis {ECO:0000255|HAMAP-Rule:MF_00166};
GN Name=fis {ECO:0000255|HAMAP-Rule:MF_00166};
GN OrderedLocusNames=YpAngola_A1212;
OS Yersinia pestis bv. Antiqua (strain Angola).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=349746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Angola;
RX PubMed=20061468; DOI=10.1128/jb.01518-09;
RA Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA Achtman M., Lindler L.E., Ravel J.;
RT "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT new insights into the evolution and pangenome of the plague bacterium.";
RL J. Bacteriol. 192:1685-1699(2010).
CC -!- FUNCTION: Activates ribosomal RNA transcription. Plays a direct role in
CC upstream activation of rRNA promoters. {ECO:0000255|HAMAP-
CC Rule:MF_00166}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00166}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Fis family.
CC {ECO:0000255|HAMAP-Rule:MF_00166}.
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DR EMBL; CP000901; ABX88240.1; -; Genomic_DNA.
DR RefSeq; WP_002210061.1; NZ_CP009935.1.
DR AlphaFoldDB; A9R1Z3; -.
DR SMR; A9R1Z3; -.
DR GeneID; 82552666; -.
DR KEGG; ypg:YpAngola_A1212; -.
DR PATRIC; fig|349746.12.peg.2167; -.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR HAMAP; MF_00166; DNA_binding_Fis; 1.
DR InterPro; IPR005412; Fis_DNA-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR PANTHER; PTHR47918; DNA-BINDING PROTEIN FIS; 1.
DR PANTHER; PTHR47918:SF1; DNA-BINDING PROTEIN FIS; 1.
DR Pfam; PF02954; HTH_8; 1.
DR PIRSF; PIRSF002097; DNA-binding_Fis; 1.
DR PRINTS; PR01591; DNABINDNGFIS.
DR PRINTS; PR01590; HTHFIS.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..98
FT /note="DNA-binding protein Fis"
FT /id="PRO_1000097469"
FT DNA_BIND 74..93
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00166"
SQ SEQUENCE 98 AA; 11197 MW; 3C20BD7A39BDC7C2 CRC64;
MFEQRVNSDV LTVATVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVSDL YELVLAEVEQ
PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN
//
