ID FTCR_BRUME Reviewed; 227 AA.
AC Q8YDL7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=Flagellar transcriptional regulator FtcR;
GN Name=ftcR; OrderedLocusNames=BMEII0158;
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
RN [2]
RP FUNCTION IN REGULATION OF FLAGELLAR GENES, INTERACTION WITH VJBR, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=17056750; DOI=10.1128/jb.00712-06;
RA Leonard S., Ferooz J., Haine V., Danese I., Fretin D., Tibor A.,
RA de Walque S., De Bolle X., Letesson J.-J.;
RT "FtcR is a new master regulator of the flagellar system of Brucella
RT melitensis 16M with homologs in Rhizobiaceae.";
RL J. Bacteriol. 189:131-141(2007).
CC -!- FUNCTION: Required for transcription of the fliF gene during vegetative
CC and intracellular growth and for production of the two flagellar
CC components flgE and fliC during vegetative growth. Specifically binds
CC to the fliF promoter region. Could mediate the action of VjbR on
CC flagellar gene expression. {ECO:0000269|PubMed:17056750}.
CC -!- DISRUPTION PHENOTYPE: Inactivation of the ftcR gene down-regulates the
CC activity of the fliF promoter region and the production of both flgE
CC and fliC proteins during vegetative growth or during macrophage
CC infection. This mutant also lacks the flagellar structures under growth
CC conditions in which the wild-type strain is flagellated. The mutant is
CC not attenuated in cellular infection models but exhibits a marked
CC virulence defect after 4 weeks or more of infection in mice.
CC {ECO:0000269|PubMed:17056750}.
CC -!- MISCELLANEOUS: There is no cognate histidine kinase partner identified
CC so far for FtcR.
CC -!- CAUTION: Lacks the conserved Asp residue in position 50 usually
CC required for phosphorylation. The Glu residue in position 50 may mimic
CC constitutive phosphorylation and allow FtcR to bypass the requirement
CC for phosphorylation. {ECO:0000305}.
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DR EMBL; AE008918; AAL53399.1; -; Genomic_DNA.
DR PIR; AD3529; AD3529.
DR RefSeq; WP_002966643.1; NZ_GG703779.1.
DR AlphaFoldDB; Q8YDL7; -.
DR SMR; Q8YDL7; -.
DR GeneID; 45054123; -.
DR KEGG; bme:BMEII0158; -.
DR KEGG; bmel:DK63_3087; -.
DR PATRIC; fig|224914.52.peg.3231; -.
DR eggNOG; COG0745; Bacteria.
DR PhylomeDB; Q8YDL7; -.
DR PRO; PR:Q8YDL7; -.
DR Proteomes; UP000000419; Chromosome II.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; REGULATOR OF RPOS; 1.
DR PANTHER; PTHR48111:SF78; TRANSCRIPTIONAL REGULATORY PROTEIN TCTD; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..227
FT /note="Flagellar transcriptional regulator FtcR"
FT /id="PRO_0000319612"
FT DOMAIN 1..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 127..226
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 227 AA; 25738 MW; 8F95853C781A7748 CRC64;
MIVVVDDRDM VTEGYSSWFG REGITTTGFT PTDFDEWVES VPEQDIMAIE AFLIGECADQ
HRLPARIRER CKAPVIAVND RPSLEHTLEL FQSGVDDVVR KPVHVREILA RINAIRRRAG
ASATSGADGT QLGPIRVFSD GRDPQINGID FPLPRRERRI LEYLIANRGR RLNKVQIFSA
IYGIFDSEVE ENVVESHISK LRKKLRGQLG FDPIDSKRFL GYCINIE
//
