ID G0A5C0_METMM Unreviewed; 1052 AA.
AC G0A5C0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:AEG01626.1};
GN OrderedLocusNames=Metme_3254 {ECO:0000313|EMBL:AEG01626.1};
OS Methylomonas methanica (strain MC09).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomonas.
OX NCBI_TaxID=857087 {ECO:0000313|EMBL:AEG01626.1, ECO:0000313|Proteomes:UP000008888};
RN [1] {ECO:0000313|EMBL:AEG01626.1, ECO:0000313|Proteomes:UP000008888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC09 {ECO:0000313|EMBL:AEG01626.1,
RC ECO:0000313|Proteomes:UP000008888};
RX PubMed=22123758; DOI=10.1128/JB.06267-11;
RA Boden R., Cunliffe M., Scanlan J., Moussard H., Kits K.D., Klotz M.G.,
RA Jetten M.S., Vuilleumier S., Han J., Peters L., Mikhailova N., Teshima H.,
RA Tapia R., Kyrpides N., Ivanova N., Pagani I., Cheng J.F., Goodwin L.,
RA Han C., Hauser L., Land M.L., Lapidus A., Lucas S., Pitluck S., Woyke T.,
RA Stein L., Murrell J.C.;
RT "Complete Genome Sequence of the Aerobic Marine Methanotroph Methylomonas
RT methanica MC09.";
RL J. Bacteriol. 193:7001-7002(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MC09;
RA Boden R., Cunliffe M., Scanlan J., Moussard H., Kits K.D., Klotz M.,
RA Jetten M., Vuilleumier S., Han J., Peters L., Mikhailova N., Teshima H.,
RA Tapia R., Kyrpides N., Ivanova N., Pagani I., Cheng J.-F., Goodwin L.,
RA Han C., Hauser L., Land M., Lapidus A., Lucas S., Pitluck S., Woyke T.,
RA Stein L.Y., Murrell C.;
RT "Complete genome sequence of the aerobic marine methanotroph Methylomonas
RT methanica MC09.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000008888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC09 {ECO:0000313|Proteomes:UP000008888};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Stein L., Woyke T.;
RT "Complete sequence of Methylomonas methanica MC09.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002738; AEG01626.1; -; Genomic_DNA.
DR RefSeq; WP_013819853.1; NC_015572.1.
DR AlphaFoldDB; G0A5C0; -.
DR STRING; 857087.Metme_3254; -.
DR KEGG; mmt:Metme_3254; -.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG3221; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_49_6; -.
DR OrthoDB; 8553030at2; -.
DR Proteomes; UP000008888; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF12974; Phosphonate-bd; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008888};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 370..440
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 443..496
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 490..539
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 566..618
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 650..784
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 793..1047
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1052 AA; 117502 MW; 9FB6EB160DC52511 CRC64;
MALTINGFLG RVPFIYRLMP LICCLAGLPA VVDAGEAVKI GILAYRSKPQ TLAQWQPLAE
ALKQTIPDKD FVIEAFEFEE LTLAVASRQV DFVLTNPGNY IQLSKRNGLS APLATLALTD
RNADQAIMVS GGVIFCRADY GGVKTLRDLK GKTIAAIGTE SLGGYQFQAY EFQKLNGNLA
EQAKLLFTGL PQDNVVNAVL NRQASVGFVR TGVLEEMARE GKLDMQQIKI INRQQLPDYP
QLLSTRLYPE WPFAAMPQID ENLARHVAAA LFMLEDHKSI MQAIGIYGFG VPADYTSVAD
LLREMRMPPY DVVPSFTLKD IWLRYQWALL TTLLIIGLFV LLTLKLLIVK RKLVLQQKLL
LQQKQQLLES ETFLRTLIRT LPDLIWLKNA EGVYLACNPR FEGFFGAEEH VIVGKTDYDF
VDRELADSFR AQDLLSMQKD GPVLSERWVT FLGDGHRELL ETRKIPMRNA AGEFVGVLGI
GHDITKRKQA EEKLLLAASV FTHAREGILI TGVDGKIIDV NDTFTAITGY SREEVLNRNP
RMLKSDRQSR AFYTAMWADL NEKGEWSGEL WNRRKNGQLY AEILTISAVR DAQGNTQHYV
ALFSDITPFK EYEQQLERIA HYDALTSLPN RILLADRLRL AMTQAQRRGM KVAVVFLDLD
GFKAVNDTYG HDMGDELLMT LASRMKQALR ESDTLARLGG DEFVAVLVDL PDTEACLPLL
SRLLTAASQP VVFGELNMLV SASLGVSFYP QAEEIDADQL LRQADQAMYQ AKLTGKNRYH
LFDADRDGSV RSLYESLEHI ARALENREFV LHYQPKVNMR TAEVLGVEAL IRWQHPEKGL
LSPASFLPVV ENHPLAIEIG EWVIETALGQ LEEWQTAGLD LPVSVNVGAR QLQRAGFVKR
LQSMLAAHQT IRPGHLEIEM QENSALEDIG AVSQVMHACR DIGIQFTLDD FGTGYSSLTY
LKHLPVCSLK IDQSFVRDML DDADDLAILR GVIGLADTFK LGVIAEGVEN RAQADSLLQL
GCELAQGYGI APPMPPGELP GWAASWRNNP AW
//
