ID G0HCN5_CORVD Unreviewed; 783 AA.
AC G0HCN5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Drug exporter of the RND superfamily {ECO:0000313|EMBL:AEK35610.1};
GN Name=mmpL3 {ECO:0000313|EMBL:AEK35610.1};
GN OrderedLocusNames=CVAR_0262 {ECO:0000313|EMBL:AEK35610.1};
OS Corynebacterium variabile (strain DSM 44702 / CIP 107183 / JCM 12073 /
OS NCIMB 30131) (Corynebacterium mooreparkense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=858619 {ECO:0000313|EMBL:AEK35610.1, ECO:0000313|Proteomes:UP000006659};
RN [1] {ECO:0000313|EMBL:AEK35610.1, ECO:0000313|Proteomes:UP000006659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44702 / JCM 12073 / NCIMB 30131
RC {ECO:0000313|Proteomes:UP000006659};
RX PubMed=22053731; DOI=10.1186/1471-2164-12-545;
RA Schroeder J., Maus I., Trost E., Tauch A.;
RT "Complete genome sequence of Corynebacterium variabile DSM 44702 isolated
RT from the surface of smear-ripened cheeses and insights into cheese ripening
RT and flavor generation.";
RL BMC Genomics 12:545-545(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002917; AEK35610.1; -; Genomic_DNA.
DR RefSeq; WP_014008804.1; NC_015859.1.
DR AlphaFoldDB; G0HCN5; -.
DR STRING; 858619.CVAR_0262; -.
DR KEGG; cva:CVAR_0262; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_5_1_11; -.
DR OMA; SRAYLNW; -.
DR Proteomes; UP000006659; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN YDFJ; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..371
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 477..693
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 711..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 83826 MW; AFDB04561BA8636F CRC64;
MFTRWGDIAY RWRRVVPVIV VAVIALLYLL VGTKLGDRMS SEGWDDPHSE STRAAQIEQD
VFGRDASGDV ILLVTRDNPD TDLSSEEVRT DFTRQLNAIS SSHPDQVRQT LSYFDGQQAQ
LITDDGSAAF ASVSLQGVED EVLKNYREIE DALHSIEVPG ATVEVAGATA VSGALDTGMS
DDIARAEVIG LPAVALLLIL VFGSVVAACM PLLVGVLSIL GSMGVLSLLA DITMVNTFAQ
SVVTLLGLGL AIDYGLFMVS RYREELAEGR DVRTAVRNTT ASAGKTVVFS ALMVAVALSS
LLLFPQAFLK SVAYGAISAV GLAALLSVIV LPSVFALLGR NIDKWTLFHR GRTKEDTVNS
WWGRVPAFAM RHAKVLTVGL VGVLLLLTIP LGGVKFGGIN ETFLPPDDTT RVAQNNFDEN
FPELRTDPVK LVIRQDDGTS AVGQVYQQAN AVEGLTGQFQ VSQPTKDGVT VLSAGIADRD
DNDRIVNELR DIKVDGAEVL VAGTPAMEVE SIDALFGKLP WMLLYIIVAT FILLSLVFGS
VILPAKAVIM NLLGTGATLG ILTWMFVDGF GADLFNFSPG PLMSPVLVLI VAIVYGLSTD
YEVFLVSRMV EARAHGASTK EAIRFGTATT GGIITAAAAI MIVVCGAFGF SSIVMMKYIA
FGMIAALVID ATIIRMLLVP ALMALLREDC WWAPTWVTRI SEKIGHNERL EGVDASTAPT
PAAAERSDEG SERSLRRTSA VSVATEDGNV GANSGAGAHE DGPVPFAELM ARLERDRRND
RKD
//