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Database: UniProt
Entry: G0HFL8_CORVD
LinkDB: G0HFL8_CORVD
Original site: G0HFL8_CORVD 
ID   G0HFL8_CORVD            Unreviewed;       440 AA.
AC   G0HFL8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN   ECO:0000313|EMBL:AEK37271.1};
GN   OrderedLocusNames=CVAR_1918 {ECO:0000313|EMBL:AEK37271.1};
OS   Corynebacterium variabile (strain DSM 44702 / JCM 12073 / NCIMB 30131)
OS   (Corynebacterium mooreparkense).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=858619 {ECO:0000313|EMBL:AEK37271.1, ECO:0000313|Proteomes:UP000006659};
RN   [1] {ECO:0000313|EMBL:AEK37271.1, ECO:0000313|Proteomes:UP000006659}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44702 / JCM 12073 / NCIMB 30131
RC   {ECO:0000313|Proteomes:UP000006659};
RX   PubMed=22053731; DOI=10.1186/1471-2164-12-545;
RA   Schroeder J., Maus I., Trost E., Tauch A.;
RT   "Complete genome sequence of Corynebacterium variabile DSM 44702
RT   isolated from the surface of smear-ripened cheeses and insights into
RT   cheese ripening and flavor generation.";
RL   BMC Genomics 12:545-545(2011).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP002917; AEK37271.1; -; Genomic_DNA.
DR   RefSeq; WP_014010427.1; NC_015859.1.
DR   STRING; 858619.CVAR_1918; -.
DR   EnsemblBacteria; AEK37271; AEK37271; CVAR_1918.
DR   KEGG; cva:CVAR_1918; -.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   KO; K03601; -.
DR   OMA; NARRRWP; -.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000006659; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 2.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006659};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:AEK37271.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006659}.
FT   DOMAIN       15    109       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      132    335       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   DOMAIN      328    406       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   440 AA;  48034 MW;  72D7372C20EE2FD8 CRC64;
     MSESPGPTTA DSPWHVHTVN EKVKGWIERL GHLWVEGQIT QLNMKPSWKL SYITLRDVSQ
     EQSIKLTCST QTLRNLPVPV KNGDRVVVYG KPAFYAVRGE FSLWVSQIRP VGVGEMLARI
     EELKRALAAE GLFDPRLKRP LPFLPNRIGL ITGRESAAEH DVLSVSRDRW PVVRFETINT
     PVQGSQAVPA ILDALRTLEA DPRVDVIIVA RGGGSVEDLL PFSEEALARA VSSMTTPVVS
     AIGHEPDNPV LDNVADLRAA TPTDAAKRVV PDVAAELSLI AELRGRAAGA LRSWVANEQR
     GLASVRSRPV LADPMLPITR AREVVEDARS RNDRALGVLV RTARHQVESL RARVNALGPS
     QTLRRGYAVV QVVPRDHTPP QVITTVDDVE PGSQLRIRVL DGSVTAAAMG VQKSPTNTQT
     APDTETDPET DTETEESTDE
//
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