ID G0HKF3_THES4 Unreviewed; 473 AA.
AC G0HKF3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=TldD/PmbA family zinc-dependent protease {ECO:0000313|EMBL:AEK72084.1};
GN OrderedLocusNames=GQS_00905 {ECO:0000313|EMBL:AEK72084.1};
OS Thermococcus sp. (strain CGMCC 1.5172 / 4557).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=1042877 {ECO:0000313|EMBL:AEK72084.1, ECO:0000313|Proteomes:UP000000874};
RN [1] {ECO:0000313|EMBL:AEK72084.1, ECO:0000313|Proteomes:UP000000874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.5172 / 4557 {ECO:0000313|Proteomes:UP000000874};
RX PubMed=21914870; DOI=10.1128/JB.05851-11;
RA Wang X., Gao Z., Xu X., Ruan L.;
RT "Complete genome sequence of Thermococcus sp. strain 4557, a
RT hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent
RT area.";
RL J. Bacteriol. 193:5544-5545(2011).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP002920; AEK72084.1; -; Genomic_DNA.
DR RefSeq; WP_014011769.1; NC_015865.1.
DR AlphaFoldDB; G0HKF3; -.
DR STRING; 1042877.GQS_00905; -.
DR GeneID; 11014829; -.
DR KEGG; the:GQS_00905; -.
DR PATRIC; fig|1042877.9.peg.180; -.
DR eggNOG; arCOG00321; Archaea.
DR HOGENOM; CLU_026425_1_2_2; -.
DR OrthoDB; 98233at2157; -.
DR Proteomes; UP000000874; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR PANTHER; PTHR30624:SF11; ZINC-DEPENDENT PROTEASE, TLDD_PMBA FAMILY; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:AEK72084.1}.
FT DOMAIN 20..84
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 114..202
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 232..447
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 473 AA; 53315 MW; 6E666B65E3A2816D CRC64;
MHELVEFAVE KALELGASYA EARFEEKNGT SLAMKNGNPE GLEILADRGI GIRVLVGGGM
GFASTNVLTK ESVSEAVKKA VKLARAASKV RNEPIRFSEE DFHRVSYKVK MKKDFRDVSP
EEKLEILRKI EEEVKAAGVN VPMRYLMYSD QLWKKVFVNS EGAYVKSKIP RVSVTYNLVV
FENGQMEQAP FVQRAFSGGL ELIEKDEPWS WAVKDVEALK KLIYEGKKPP EGKVDLVISP
EVAGIAVHES VGHPYESDRI FGREAAQAGE SFVKPDMLGE RIGSEAVTVI EDPTLPNSWG
FYLYDDEGVK ARPRYLIKDG IITEFLTNRE YAYKLGQRSN AAARAINYNR EPIVRMANTY
LAPGDHSFEE LIEDIKLGVY MVSFNEWNID DRRYQQRYIG REAYLIENGE IKHPVRRPIL
EITTRALWSS VDAVGKEVEY YPGTCGKGEP GQGVPVWMGG AHARLRDIPL RRP
//
