ID G0HRR6_HALHT Unreviewed; 720 AA.
AC G0HRR6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Protporphyrin IX magnesium chelatase {ECO:0000313|EMBL:AEM55899.1};
DE EC=6.6.1.1 {ECO:0000313|EMBL:AEM55899.1};
GN Name=hmcA {ECO:0000313|EMBL:AEM55899.1};
GN OrderedLocusNames=HAH_0273 {ECO:0000313|EMBL:AEM55899.1};
OS Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182
OS / NCIMB 2187 / VKM B-1755).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=634497 {ECO:0000313|EMBL:AEM55899.1, ECO:0000313|Proteomes:UP000005629};
RN [1] {ECO:0000313|EMBL:AEM55899.1, ECO:0000313|Proteomes:UP000005629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 /
RC VKM B-1755 {ECO:0000313|Proteomes:UP000005629};
RX PubMed=21994921; DOI=10.1128/JB.05953-11;
RA Liu H., Wu Z., Li M., Zhang F., Zheng H., Han J., Liu J., Zhou J., Wang S.,
RA Xiang H.;
RT "Complete genome sequence of Haloarcula hispanica, a model haloarchaeon for
RT studying genetics, metabolism, and virus-host interaction.";
RL J. Bacteriol. 193:6086-6087(2011).
CC -!- SIMILARITY: Belongs to the Mg-chelatase subunits D/I family.
CC {ECO:0000256|ARBA:ARBA00005799}.
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DR EMBL; CP002921; AEM55899.1; -; Genomic_DNA.
DR RefSeq; WP_014039274.1; NC_015948.1.
DR AlphaFoldDB; G0HRR6; -.
DR STRING; 634497.HAH_0273; -.
DR GeneID; 25155951; -.
DR KEGG; hhi:HAH_0273; -.
DR eggNOG; arCOG00438; Archaea.
DR HOGENOM; CLU_016684_4_0_2; -.
DR OrthoDB; 25914at2157; -.
DR Proteomes; UP000005629; Chromosome I.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0016851; F:magnesium chelatase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.8.80; Magnesium chelatase subunit I, C-Terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR045006; CHLI-like.
DR InterPro; IPR041628; ChlI/MoxR_AAA_lid.
DR InterPro; IPR000523; Mg_chelatse_chII-like_cat_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR32039; MAGNESIUM-CHELATASE SUBUNIT CHLI; 1.
DR PANTHER; PTHR32039:SF9; MAGNESIUM-CHELATASE SUBUNIT CHLI-1, CHLOROPLASTIC; 1.
DR Pfam; PF17863; AAA_lid_2; 1.
DR Pfam; PF01078; Mg_chelatase; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000313|EMBL:AEM55899.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 549..720
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 321..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..386
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 75129 MW; CB7CCBF5A800D777 CRC64;
MVVLGDGKKA SQEASFAAVV GQRDLKDGLL AVATDDDLDG LLVRGEKGTA KSTAVRALAD
LLPEQRAVAD CPYGCPPDRP EAQCDDCRTR ADPPVETRSV PLVTLPLGAT RDRVVGTLSV
ADALDGDHEF DPGLLARANR GILYVDEVNL LDDHLVDVLL DAAASGQNRV ERDGVTVSHP
AEFTLVGTMN PEEGDLRPQL RDRFALQTEV SACENLDDRV AIIDQALGED GDEEMQSEPD
RDPGERLRTA RELLPEVALA REFREQIAEL CRDAGLDGHR GDIATARAAR TFAALDGRTT
VLESDIERAA EFALPHRLTS RPFEDAPDVD DVLDDHFEDG EDESEEQSDD DGENGDEEGD
AEDDGEEAGA GDESVNDGAD SEGGEDGSEQ QEQRPDDSGD AGEGGDDESG ERGEQPTPTS
ADSDGERQEA EAGDGEGAAG DDGGEGESNQ SDDPENATPL LPGQSRATVG DSGAPDVDAP
SVDTDGGSAS GRASATGTKR GATVRTERAG RDDEVDAAAS VRAAASRGSG HVESRDLRKS
VRAGDAETLV VFAVDASASM RPAMKAAKGT VLELLKDAYQ ARDQVAFVTF AGEGADVVLP
PTESVSLAAR HLKDLPTGDR TPLPDGLAAA REVLDRADPD AGVVVVVTDG RANTADGSPV
AATRNAARTL GEAADRTVVV DAGEGSRAGL LDLVADETDA SVVPLDALTA ERVDAVASKR
//
