ID G0HVP2_HALHT Unreviewed; 447 AA.
AC G0HVP2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|ARBA:ARBA00012134};
DE EC=1.4.4.2 {ECO:0000256|ARBA:ARBA00012134};
GN Name=gcvPA {ECO:0000313|EMBL:AEM57664.1};
GN OrderedLocusNames=HAH_2070 {ECO:0000313|EMBL:AEM57664.1};
OS Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182
OS / NCIMB 2187 / VKM B-1755).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=634497 {ECO:0000313|EMBL:AEM57664.1, ECO:0000313|Proteomes:UP000005629};
RN [1] {ECO:0000313|EMBL:AEM57664.1, ECO:0000313|Proteomes:UP000005629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 /
RC VKM B-1755 {ECO:0000313|Proteomes:UP000005629};
RX PubMed=21994921; DOI=10.1128/JB.05953-11;
RA Liu H., Wu Z., Li M., Zhang F., Zheng H., Han J., Liu J., Zhou J., Wang S.,
RA Xiang H.;
RT "Complete genome sequence of Haloarcula hispanica, a model haloarchaeon for
RT studying genetics, metabolism, and virus-host interaction.";
RL J. Bacteriol. 193:6086-6087(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839};
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DR EMBL; CP002921; AEM57664.1; -; Genomic_DNA.
DR RefSeq; WP_014040817.1; NC_015948.1.
DR AlphaFoldDB; G0HVP2; -.
DR STRING; 634497.HAH_2070; -.
DR GeneID; 23805303; -.
DR KEGG; hhi:HAH_2070; -.
DR eggNOG; arCOG00077; Archaea.
DR HOGENOM; CLU_004620_0_2_2; -.
DR OrthoDB; 17655at2157; -.
DR Proteomes; UP000005629; Chromosome I.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR CDD; cd00613; GDC-P; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR023010; GcvPA.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR42806; GLYCINE CLEAVAGE SYSTEM P-PROTEIN; 1.
DR PANTHER; PTHR42806:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING); 1.
DR Pfam; PF02347; GDC-P; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AEM57664.1}.
FT DOMAIN 13..434
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
SQ SEQUENCE 447 AA; 48010 MW; B7D5FC0CE663CDF0 CRC64;
MSDSDSHATG SPYAPQTAAE TAAMLDAVGA DDLESLFDVP ESVAFDGEFG IDARSERAAR
REVAGLLGRN ADLTEFLGRG HYDHYVPSVV DDLASRSEFL TSYTQYQPEV AQGFLQALFE
FQSMLVELTG LGVANCSMYD DATALGEAAT LSQRVRSVSG DRILVPEHLR EGKRTVLSNY
AEGPALTVES YPMTDGVVDV AALADQIGDD TAMVYAESPT VRGVIEERLG VVGDLAHDHE
ALFCLGSDPI ALSLLERPAD VGADVVVGDA ASLGTGTAYG FGLGMFVTRE EYLRQVPGRL
VGASEDAADR RAYTLTLQTR EQHIRKERAT SNICTNQAWV ALRTAMHAAW LGPDGLVDLA
EDCVTRARDL SDRLDDIVGV KAPIHGRHHF REFLARTDQP ASAIVADLAS EGFAVHAVED
HLVQVCATET TADATDEFVA AFREVAK
//
