ID G0I0I6_HALHT Unreviewed; 1014 AA.
AC G0I0I6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=D-lactate dehydrogenase (cytochrome) {ECO:0000256|ARBA:ARBA00038897};
DE EC=1.1.2.4 {ECO:0000256|ARBA:ARBA00038897};
GN Name=glcD3 {ECO:0000313|EMBL:AEM59407.1};
GN OrderedLocusNames=HAH_5274 {ECO:0000313|EMBL:AEM59407.1};
OS Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182
OS / NCIMB 2187 / VKM B-1755).
OG Plasmid pHH400 {ECO:0000313|EMBL:AEM59407.1,
OG ECO:0000313|Proteomes:UP000005629}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=634497 {ECO:0000313|EMBL:AEM59407.1, ECO:0000313|Proteomes:UP000005629};
RN [1] {ECO:0000313|EMBL:AEM59407.1, ECO:0000313|Proteomes:UP000005629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 /
RC VKM B-1755 {ECO:0000313|Proteomes:UP000005629};
RC PLASMID=pHH400 {ECO:0000313|EMBL:AEM59407.1,
RC ECO:0000313|Proteomes:UP000005629};
RX PubMed=21994921; DOI=10.1128/JB.05953-11;
RA Liu H., Wu Z., Li M., Zhang F., Zheng H., Han J., Liu J., Zhou J., Wang S.,
RA Xiang H.;
RT "Complete genome sequence of Haloarcula hispanica, a model haloarchaeon for
RT studying genetics, metabolism, and virus-host interaction.";
RL J. Bacteriol. 193:6086-6087(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP002923; AEM59407.1; -; Genomic_DNA.
DR RefSeq; WP_014031256.1; NC_015944.1.
DR AlphaFoldDB; G0I0I6; -.
DR GeneID; 23803148; -.
DR KEGG; hhi:HAH_5274; -.
DR eggNOG; arCOG00337; Archaea.
DR HOGENOM; CLU_010756_0_0_2; -.
DR OMA; GNDACGN; -.
DR OrthoDB; 2837at2157; -.
DR Proteomes; UP000005629; Plasmid pHH400.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 2.
DR Gene3D; 3.30.70.2740; -; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF111; D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02754; CCG; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Plasmid {ECO:0000313|EMBL:AEM59407.1};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 62..298
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 660..692
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 110072 MW; EFB4D1FC1B0AB0B8 CRC64;
MAYDSRPPEE RDPATDPSAN YDYQGESVHR PDLVAVLERR VDGDVRFDTY TRELFATDAS
AYEQRPIGVV SPVSTDDVVT VMEYCAEQGI PVLPRGGGTS LAGQAVNEAV VLDFKRHMDE
TLSVDPEAGR ARAQAGITIA RLNDRLEPHG LKFAPDPAWG DKSVLGGAIG NNTTGAHSLK
YGKTDAYIEE CEVVLADGTQ TTFGWVGVDD LKARAAEAGP DADLETRIYA EVAKILAEDA
AEIDDKYPDL KRNVSGYNLD ELVDSARERG EVNLARLLAG SEGTLAVVTE ATVSLEPVPQ
ATAVAMLTYD DILSAMRDVA PILDHDPSAV EVMDDVLLDL AAETPEFADV VGMLPEETDS
TLLVEFYADS ADDGAQKVAD LLADRLPDYD ARESPSEGAA AVTDAPVNAV DALEAYDADR
QAKFWKMRKA GLPILLSRTG DDKHWPFVED TAVPAENLPE YVADIRELFD EHDTFASYYA
HAGPGVLHIR PLLNLKSGDG IETMEAISDA ITDLVVQYDG SVSGEHGDGR ARTQWNRKLY
GDDLWETFRD LKTAFDPDWR LNPGNICGDH DPAENLRYDP DYEFDAGFEP TLDWDNENGF
QGMVELCHGC AGCTVHQETT GGVMCPTYRA AEEEITSTRG RANMLRSAMD GDLPEDPTDE
EFVTEVLDLC IGCKGCKKDC PSGVDMAKLK AEVVHEHHQR EGISLRDRLF ANVETVLSLG
SAFAPMSNWL LDLPGSGLLM EKTVGITEER TLPAFHRTTF RDWWADRGGA LIAANKAERK
ALVIADPYTN YSHPDVGKAA VEVLEAAGVH VVVPDGVTDS GRPAFSKSML DHARETARAN
VDVLAPRIRD GWDVVTIEPS DAVMYQVDYR DLLSGDDVDT VAANTYGVCE YLDTYRLGEA
ISFDEPGGSL AYHGHCHQKA TKKDHHAVGV LRRAGYAVDP LDSGCCGMAG SFGYEAEHYS
MSEGIADLLL GQIDDSPAER VVAPGASCRS QIDDFGDGDA EPPHPIEMVA AALQ
//