ID G0IW80_CYCMS Unreviewed; 748 AA.
AC G0IW80;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=Cycma_2561 {ECO:0000313|EMBL:AEL26300.1};
OS Cyclobacterium marinum (strain ATCC 25205 / DSM 745 / LMG 13164 / NCIMB
OS 1802) (Flectobacillus marinus).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Cyclobacterium.
OX NCBI_TaxID=880070 {ECO:0000313|EMBL:AEL26300.1, ECO:0000313|Proteomes:UP000001635};
RN [1] {ECO:0000313|Proteomes:UP000001635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25205 / DSM 745 / LMG 13164 / NCIMB 1802
RC {ECO:0000313|Proteomes:UP000001635};
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Chertkov O.,
RA Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Schuetze A.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Cyclobacterium marinum DSM 745.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP002955; AEL26300.1; -; Genomic_DNA.
DR RefSeq; WP_014020593.1; NC_015914.1.
DR AlphaFoldDB; G0IW80; -.
DR STRING; 880070.Cycma_2561; -.
DR KEGG; cmr:Cycma_2561; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_10; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000001635; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001635}.
FT DOMAIN 5..290
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 291..566
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 678..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 748 AA; 85852 MW; CF4A5BE0DC59AA9D CRC64;
MEYLATLNPP QLEAVKKTEG PVMIIAGAGS GKTRVLTYRI AHLIHEKKVD AFQILSLTFT
NKAASEMKQR IEKLIGLEAR NTWMGTFHSV FAKILRVEAQ KLGYPSNFTI YDSDDSKSLI
RSIVKEMKLD DKVYKANTVL SRISGAKNRL IGWQAYLNDP YITADDEAAM KPKMGEIYKA
YQSRLFRSSA MDFDDLLFNT NILFRDHPDV LNKYQQRFRY VMVDEFQDTN LSQYLITKKL
AAVHQNICVV GDDAQSIYAF RGADIQNILN FEKDYPDLLV VKLEQNYRST KNIVETANSI
IAKNKSQLKK NVWTQNDSGD LIELMKASSD NEEGRMVAAT IFEEKNNKQL SNSDFAILYR
TNSQSRSMEE ALRKSGIAYR IIGGLSFYQR KEIKDLMGYF RFVVNHEDEE AFKRIINYPK
RGIGNTSVEK LMVGAYEHDI SLWKVLNNSQ SFISGRGANA VTDFCTMINS FKMEVERKDA
FEAATFIAKQ SGLLRDLYED KTIEGLNRYE NVQELLNAIK EYVDNPENED KSLGAFLQEI
ALLTDEDQNK NNQDTVTMMT IHSSKGLEFK YVFVVGMEED LFPSQMMMQS REDLEEERRL
FYVATTRAME KLYFSYALTR YRYGRLLNCE PSRFLEEIDP TFIKVNKKLS SKLSSSFRES
EGKQGFVGLK KKPAIRNTTT KLHDPGPNFK PSNTNNLKEG MKVEHPKFGF GKVHGIETEG
TNRKAHIHFD HFGDKTLLLS FAKLRIVE
//
