ID   G0IWE3_CYCMS            Unreviewed;       676 AA.
AC   G0IWE3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Peptidase M3A and M3B thimet/oligopeptidase F {ECO:0000313|EMBL:AEL27131.1};
GN   OrderedLocusNames=Cycma_3408 {ECO:0000313|EMBL:AEL27131.1};
OS   Cyclobacterium marinum (strain ATCC 25205 / DSM 745 / LMG 13164 / NCIMB
OS   1802) (Flectobacillus marinus).
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC   Cyclobacterium.
OX   NCBI_TaxID=880070 {ECO:0000313|EMBL:AEL27131.1, ECO:0000313|Proteomes:UP000001635};
RN   [1] {ECO:0000313|Proteomes:UP000001635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25205 / DSM 745 / LMG 13164 / NCIMB 1802
RC   {ECO:0000313|Proteomes:UP000001635};
RA   Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Chertkov O.,
RA   Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Schuetze A.,
RA   Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Cyclobacterium marinum DSM 745.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU003435};
CC       Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002955; AEL27131.1; -; Genomic_DNA.
DR   RefSeq; WP_014021421.1; NC_015914.1.
DR   AlphaFoldDB; G0IWE3; -.
DR   STRING; 880070.Cycma_3408; -.
DR   KEGG; cmr:Cycma_3408; -.
DR   eggNOG; COG0339; Bacteria.
DR   HOGENOM; CLU_001805_4_0_10; -.
DR   OrthoDB; 9773538at2; -.
DR   Proteomes; UP000001635; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06456; M3A_DCP; 1.
DR   Gene3D; 1.10.1370.40; -; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR034005; M3A_DCP.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR43660; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR   PANTHER; PTHR43660:SF1; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003435};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU003435};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001635};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT   DOMAIN          225..673
FT                   /note="Peptidase M3A/M3B catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01432"
SQ   SEQUENCE   676 AA;  76974 MW;  1108E76DC22CF128 CRC64;
     MNPLLAKFNT PFETAPFDKI KNEHFLPAIQ NGIAEVKEEI KKIKTSTPPD FENTIVALEN
     SGEKLSRAAS IFFNINAAET NDEIQQLARE ISPLLSAHSN DILLDETLFK RVKAVFDQRD
     QLKLTPEQST LLEKSYKSFI RNGALLKGDD KDRLRAIDQE LSKLGLHFGE NVLKETNKYE
     LVVAEAKDLE GLPDGLIEAA AQTAQEKGKE GKWIFTLAFP SYVPFMTYAK NRELRKELYI
     AYNTKSAKGD ELDNRQIIKN ILKLKDERAK LLGYDNYADF VLEERMAEGG EKVLSFLDEL
     LEKAKPRAIS ELKELEAFAK KTDGIEKLFK WDISYYAEKL KMEKYAVDDE LLKPYFELNR
     TIDGVFTTAE KLYGITFKEN KAIPVYHPDV KAYEVKDEKG DHLAVFYADF FPRAGKRNGA
     WMTAYRGQRK IGNKENRPHV SIVCNFTKPT KTKPSLLTFN EVTTLFHEFG HALHGMLAQG
     TYGSLSGTNV YWDFVELPSQ IFENWCYEEE CLDLFAKHYE TGEPIPKSYI ENIKKAANFH
     QGFQTARQIS LGQLDMAYHT TAPDAIDDVF EFENDVMKPT ALLDPVPNTM ISTSFSHIFQ
     GGYAAGYYSY KWAEVLDADA FELFQEKGVF DKATAKSFKE NILSMGGKEH PSILYKRFRG
     RAPKPDALIK RAGLQV
//